Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2009-07-26
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2009

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
GLP compliance:
no
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Capa monomer
- Name of test material (as cited in study report): Capa® Monomer
- Substance type: organic
- Physical state: liquid
- Analytical purity: GC area% 99.8
- Lot/batch No.: WNI 5862 26/5/09
- Stability under test conditions: stable
- Storage condition of test material: room temperature

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
0.32
Temp.:
20 °C

Any other information on results incl. tables

Substance

log Pow

tR

Ethanol

-0.30

2.39

Methylethylketone

0.29

2.78

Benzyl alcohol

1.05

3.50

2-ethylhexanol

2.82

21.62

1-octanol

3.07

29.55

Cumene

3.66

55.14

A linear regression coefficient was calculated using these references and the retention times of their peaks.

 

intercept

1.612

slope

1.352

corr. coeff.

0.999

 

The Log Powof the tested substance was calculated from this. Duplicate determinations were made.

 

Results:                                                                           

 

 

tR

log Pow

Inj 1

2.70

0.312

Inj 2

2.71

0.327

Applicant's summary and conclusion

Conclusions:
Log Pow: 0.32 at 20 °C
Executive summary:

Log Pow: 0.32 at 20 °C