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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2009-07-26
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: guideline study
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
GLP compliance:
no
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- batch No.of test material: WNI 5862 26/5/09
- Expiration date of the lot/batch:
- Purity test date: 99.8 %

Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
0.32
Temp.:
20 °C
pH:
4.8
Remarks on result:
other: S.D. 0.011

Table 1. LogP ow of reference substances

Substance

log Pow

tR

Ethanol

-0.30

2.39

Methylethylketone

0.29

2.78

Benzyl alcohol

1.05

3.50

2-ethylhexanol

2.82

21.62

1-octanol

3.07

29.55

Cumene

3.66

55.14

A linear regression coefficient was calculated using these references and the retention times of their peaks.

 

intercept

1.612

slope

1.352

corr. coeff.

0.999

 

The Log Powof the tested substance was calculated from this. Duplicate determinations were made.

 

Results:                                                                          

 

 

tR

log Pow

Inj 1

2.70

0.312

Inj 2

2.71

0.327

Conclusions:
The partition coefficient for the test material at 20 °C was log Pow 0.32 (S.D. 0.011)
Executive summary:

The partition coefficient was measured for the test material following the OECD 117 guideline. The study was reliable with restriction (Klimish 2). Results indicated that at 20 °C, log Pow was 0.32 (S.D. 0.011).

Description of key information

The partition coefficient was measured for the test material following the OECD 117 guideline. The study was reliable with restrictions (Klimish 2). Results indicated that at 20 °C, log Pow was 0.32 (SD = 0.011).

Key value for chemical safety assessment

Log Kow (Log Pow):
0.32
at the temperature of:
20 °C

Additional information