Registration Dossier

Physical & Chemical properties

Additional physico-chemical information

Administrative data

Endpoint:
additional physico-chemical information
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well-doucmented publication which meets basic scientific principles

Data source

Reference
Reference Type:
publication
Title:
Electric field and vibration-assisted nanomolecule desorption and anti-biofouling for biosensor applications
Author:
Po-Ying J. Yeh, Jayachandran N. Kizhakkedathu,, John D. Madden, Mu. Chiao
Year:
2007
Bibliographic source:
Colloids and Surfaces B : Biointerfaces 59, 67-73

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Proteins were adsorbed to metal plates coated PZT surfaces. Then voltage and vibration were applied and proteins were repelled from the surface.
Fluorescence microscope studies were used to quantify the adsorbed protein.
GLP compliance:
not specified
Endpoint investigated:
other: adsorption minimizing

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Results:
Combined effect of both electric-field and vibration, is responsible for the protein desorption.
Theoretical calculations on protein-surface interactions support this mechanism.

Applicant's summary and conclusion

Conclusions:
In the conditions of the study, PZT was found to present an excellent potential for the purpose of a protein-surface adsorption/desorption system.