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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Remarks:
not performed according to guideline and GLP
Qualifier:
no guideline followed
Principles of method if other than guideline:
Hydrolysis as a Function of pH
GLP compliance:
no
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Purity: 98.1%

Radiolabelling:
no
Analytical monitoring:
yes
Details on sampling:
- Sampling intervals for the parent/transformation products: ph4: 0, 2, 3, 20, 28, 93, 121.5 h; ph7: 0, 3, 70, 72.5, 98.5, 118.5h; ph9: 0, 4, 26, 32.5, 101, 125 h
- Sampling method: 50 mL
Buffers:
- pH: 4
- Composition of buffer: citric acid, sodium chloride, sodium hydroxide
- pH: 7
- Composition of buffer: disodium hydrogen phosphate, potassium dihydrogen phosphate
- pH: 9
- Composition of buffer: sodium borate, hydrochloric acid
Details on test conditions:
TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: doublewalled 1L beaker

Duration:
5 d
pH:
4
Temp.:
50 °C
Initial conc. measured:
25 mg/L
Duration:
5 d
pH:
7
Temp.:
50 °C
Initial conc. measured:
25 mg/L
Duration:
5 d
pH:
9
Temp.:
50 °C
Initial conc. measured:
25 mg/L
Number of replicates:
3
Positive controls:
no
Negative controls:
no
Transformation products:
no
Key result
pH:
4
Temp.:
50 °C
DT50:
170 d
Type:
(pseudo-)first order (= half-life)
Remarks on result:
hydrolytically stable based on preliminary test
Key result
pH:
7
Temp.:
50 °C
DT50:
303 d
Type:
(pseudo-)first order (= half-life)
Remarks on result:
hydrolytically stable based on preliminary test
Key result
pH:
9
Temp.:
50 °C
DT50:
186 d
Type:
(pseudo-)first order (= half-life)
Remarks on result:
hydrolytically stable based on preliminary test

Less than 10% of the substance was hydrolysed after 5 days.

Validity criteria fulfilled:
not applicable

Description of key information

In contact with water the substance will hydrolyse slowly.

Key value for chemical safety assessment

Additional information

Hydrolysis as a function of pH was tested at a temperature of 50°C [BASF AG 1990]. Less than 10% of the substance was hydrolysed after 5 days. Based on this result a half-life of more than 1 year can be expected under environmental conditions (25°C).