Registration Dossier
Registration Dossier
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EC number: 231-665-7 | CAS number: 7681-38-1
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
- Principles of method if other than guideline:
- Method: other: Salmonella/Microsome test, Ames et al, Mutation Res. 31, 347-364 (1975)
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Sodium sulphate
- EC Number:
- 231-820-9
- EC Name:
- Sodium sulphate
- Cas Number:
- 7757-82-6
- Molecular formula:
- H2O4S.2Na
- IUPAC Name:
- disodium sulfate
- Details on test material:
- IUCLID4 Test substance: as prescribed by 1.1 - 1.4
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: S. Typhimurium TA1535, TA1537, TA100, TA98
- Metabolic activation:
- with and without
- Test concentrations with justification for top dose:
- 312.5 to 5000 µg per plate with 4 dilutions
- Details on test system and experimental conditions:
- IUCLID4 Type: Ames test
Results and discussion
Test results
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- other: no cytotoxicity observed
- Remarks on result:
- other: other: S. Typhimurium TA1535, TA1537, TA100, TA98
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
RS-Freetext:
EFFECTS:
- With metabolic activation: both tests, no effects
- Without metabolic activation: both tests, no effects
FREQUENCY OF EFFECTS: n.a.
PRECIPITATION CONCENTRATION: not described
MITOTIC INDEX: not described
CYTOTOXIC CONCENTRATION: no toxicity observed up to 5000
mg/l
TEST-SPECIFIC CONFOUNDING FACTORS: not described
STATISTICAL RESULTS: n.a.
Applicant's summary and conclusion
- Conclusions:
- EFFECTS: - With metabolic activation: both tests, no effects - Without metabolic activation: both tests, no effects.
Sodium sulfate did not show mutagenic effects in the Ames test.
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