Registration Dossier
Registration Dossier
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EC number: 231-665-7 | CAS number: 7681-38-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Sodium hydrogensulfate dissociates in water to yield sodiums cations, as well as hydrogensulfate and sulfate ions in a pH-dependent equilibrium. For this reason, it is considered fully justified to also read across from existun data for sodium sulfate:
For sodium sulfate, an Ames test, a mouse lymphoma study and a chromosome aberration test is available. The Ames test did not show mutagenic effects (Bayer 1988). The in vitro mammalian cell gene mutation test (Wolny 2010) showed no substantial or reproducible dose dependent increase of the mutation frequency, and concluded on a lack of mutagenicity.
The chromosome aberration test (Hal 2010) showed no cytotoxic effects, and in both experiments in the absence and presence of S9 mix, no biologically relevant increase in the number of cells carrying structural chromosome aberrations was observed.
Based on the above test results, it is concluded that sodium sulfate has no genotoxic toxic potential.
Short description of key information:
No data specifically for sodium hydrogensulfate on genotoxicity are available, thus read-across from data on sodium sulfate was performed. Based on the absence of any indication of genotoxic effects in guideline-conform studies on bacterial reverse mutation, in-vitro cell gene mutation and in-vitro chromosomal aberration, it is concluded that sodium sulfate also lacks any genotoxic potential.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on read-across from data on sodium sulfate (i.e. negative results in AMES, in-vitro cell gene mutation and in-vitro chromosomal aberration tests), it is concluded that sodium hydrogensulfate also lacks any genotoxic potential, and the substance therefore does not require classification for genotoxicity according to EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2.
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