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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Study period:
1975
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Study is available only as abstract
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
1975

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
yes
Remarks:
1 hour LC50 determined
GLP compliance:
not specified
Test type:
other: 1 hour LC50 according to standard protocol
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
whole body
Vehicle:
air
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
1 h
Concentrations:
Mean analytical concentrations of 0.063 and 0.099 mg/L
No. of animals per sex per dose:
10
Control animals:
no

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LC50
Effect level:
> 0.099 mg/L air
Based on:
test mat.
Exp. duration:
1 h
Mortality:
No
Clinical signs:
Hypoactivity, mild to severe irritation around the muzzle, nasal discharge
Body weight:
Not affected
Gross pathology:
Yes, no findings

Applicant's summary and conclusion

Interpretation of results:
other: No indication of strong toxic potential when tested at non-corrosive concentration
Remarks:
Criteria used for interpretation of results: expert judgment
Conclusions:
The 1 hour LC 50 was found to exceed 0.099 mg/L in male rats. The symptomatology did not indicate a strong toxic potential when tested at a non-corrosive concentration.
Executive summary:

In a range finding study groups of ten male Sprague-Dawley rats were exposed to a vapour of coco alkylamines (“Armeen C”) at mean analytical concentrations of 0.063 and 0.099 mg/l for one hour by whole-body exposure. Chamber concentrations were monitored during the entire one-hour exposure period at a rate of 0.52 l/min. Rats were observed for mortality and signs of toxicity and/or abnormal behaviour throughout the exposure and daily for 14 days after the termination of exposure. Body weights were recorded prior to exposure and on day 14. All surviving rats were subjected to a gross necropsy, and the following tissues excised and preserved in 10% neutral buffer formalin: brain, liver, kidney, heart, pancreas, stomach, lungs, spleen and testes. The tissues from the animals in the 0.099 mg/l group were examined under a light microscope. There were no deaths, accordingly, the one hour LC50 was found to exceed 0.099 mg/l. After five minutes of exposure several rats in the 0.063 mg/l dose group were preening and inactive. All animals were hypoactive after ten minutes. After 40 minutes, several animals exhibited a slight irritation around the muzzle. This latter effect, as well as hypoactivity in all rats, continued for the remainder of the exposure period. After ten minutes of exposure all rats in the 0.099 mg/l dose group were hypoactive. After 30 minutes, several animals showed signs of irritation, were preening, and exhibited a nasal discharge. At the end of the one-hour exposure, all rats showed mild to severe irritation around the muzzle and had reddish areas of discoloration on the fur. All rats in both groups exhibited normal appearance and behaviour throughout the 14-day postexposure observation period. A mean body weight gain in both dose groups was noted at the end of the observation period. No necropsy findings were noted in any rats from both dose groups.