Registration Dossier

Physical & Chemical properties

Dissociation constant

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

The pKa of primary fatty amines are nearly independent from the carbon-chain-length within the range of C8 (Octyl) and C22 (docosyl). Therefore, a value of pKa = 10.6 can be taken as the default value representing unbranched primary fatty amines consisting of carbon chainlengths between C8 - C22.

Key value for chemical safety assessment

pKa at 20°C:
10.6

Additional information

The pKa of primary fatty amines are nearly independent from the carbon-chain-length within the range of C8 (Octyl) and C22 (docosyl). Therefore, a value of pKa = 10.6 can be taken as the default value representing unbranched primary fatty amines consisting of carbon chainlengths between C8 - C22.

pKa pKb Temp [°C] Solvent Method Reference
Octylamine (CAS 111-86-4)
10,65 3,35 25 water condutometric 1
11,20 2,80 18,5 water condutometric 2
10,57 3,43 25 water potentiometric 3
Decylamine (CAS 2016-57-1)
10,64 3,36 25 water condutometric 1
10,60 3,40 25 water not stated 4
9,92 4,08 25 water not stated 5
9,30 4,70 25 water not stated 6
Dodecylamine (CAS 124-22-1)
10,64 3,36 25 water condutometric 1
10,80 3,20 25 not stated not stated 7
10,63 3,37 25 water potentiometric 8
9,00 5,00 not stated not stated not stated 9
Tetradecylamine (CAS 2016-42-4)
10,62 3,38 25 water condutometric 1
Hexadecylamine (CAS 143-27-1)
10,61 3,39 25 water condutometric 1
9,13 4,87 25 water condutometric 10
Octadecylamine (CAS 124-30-1)
10,60 3,40 25 water condutometric 1
Docosanylamine (CAS 14130-06-4)
10,60 3,40 25 water condutometric 1

[1] C. W. Hoerr, M. R. McCorkle, A.W. Ralston, J. Am. Chem. Soc 1943, 65, 328.

[2] G. Vexlearschi, C. R. Hebd. Seances Acad. Sci. 1949, 228, 1656.

[3] G. Vexlearschi, Bull. Soc. Chim. Fr. 1956, 23, 589.

[4] M. Canle L., I. Demirtas, A. Freire, H. Maskill, M. Mishima, Eur. J. Org. Chem. 2004, 2004, 5031.

[5] H. Arnold et al., Tetrahedron Lett. 1969, 10, 137.

[6] W.W. Libus,W. Moska, Bull.Acad.Pol.Sci.,Ser.Sci.Chim. 1972, 20, 897.

[7] K. Gustavii, Acta Pharm. Suecica 1967, 4, 233.

[8] J. Steigman, D. Sussman, J. Am. Chem. Soc. 1967, 89, 6400.

[9] J. Zheng, S. E. Powers, Environ. Sci. Technol. 2003, 37, 3090.

[10] V. E. Belskii, K. A. Derstuganova, R. F. Bakeeva, L. A. Kudryavtseva, B. E. Ivanov, Russ. Chem. Bull., Int. Ed. 1982, 31, 2112.