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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1984
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptably documented study report.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1984
Report date:
1984

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(2-methoxyethoxy)ethanol
EC Number:
203-906-6
EC Name:
2-(2-methoxyethoxy)ethanol
Cas Number:
111-77-3
Molecular formula:
C5H12O3
IUPAC Name:
2-(2-methoxyethoxy)ethanol
Details on test material:
Sample ref: 46-350, 47-116. No further information

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
occlusive
Preparation of test site:
other: clipped fur. Intact skin
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
0.5ml
Duration of treatment / exposure:
4 hours
Observation period:
3 days. Observations scored at 5hrs, 1, 2 and 3 days
Number of animals:
3 male, 3 female
Details on study design:
TEST SITE
- Dose appplied to clipped, intact skin under a guaze patch that is loosely covered with impervious sheeting. Animals restrained during exposure. Excess removed after exposure period.

SCORING SYSTEM: Draize, measurements at 1hr, 1, 2, 3, days. Also 7, 10 and 14 days if required.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24, 48, 72 hours
Score:
0
Max. score:
4
Reversibility:
other: no effects seen
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24, 48, 72 hours
Score:
0
Max. score:
4
Reversibility:
other: no effects seen
Irritant / corrosive response data:
Irritation scores were 0 for both erythema and odema at all observation times.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The substance has no skin irritation potential.
Executive summary:

In a skin irritation study that complies with the main requirements of the appropriate OECD guideline, six rabbits were used to assess the skin irritancy of 2 -(2 -methoxyethoxy)ethanol. None of the animals showed any response indicative of irritation. The substance does not need to be classified as irritant in the EU.