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EC number: 231-867-5
CAS number: 7772-98-7
In the in vitro rat primary hepatocyte
unscheduled DNA synthese (UDS) assay, the test item, ammonium
thiosulfate solution, did not induce significant increses in UDS. In the
assay described in this report, freshly prepared rat hepatocytes were
exposed to ammonium thiosulfate solution at concentrations ranging from
5000 µg/mL to 0.5 µg/mL in the presence of 10 µCi/mL ³HTdr (40 -60
Ci/mmole). The test item was soluble in media at all concentrations
tested. Treatments from 5000 µg/mL to 500 µg/mL were not analysed for
nuclear labeling due to high toxicity. Treatments fronm 250 µg/mL to 5
µg/mL covered a good range of toxicity (65.8% to 97.1% survival) and
were selected for analysis of nuclear labeling. None of the criteria
used to indicate UDS were approached by any of the analysed treatments
and no dose-related response was observed.
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