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EC number: 231-867-5
CAS number: 7772-98-7
bisulphite reduced the cell multiplication in neuroblastoma cells.
colony-forming ability (CFA) was inhibited by 72% to 92% at a 3-h
exposure to one commercial sample of sodium bisulphite and by 57% to 72%
with another sample (both tested at concentrations of 0.8 mM).
difference in the inhibition of CFA was detected between both commercial
samples at concentrations below 0.8 mM
Prolongation of exposure time to 20 hours resulted in a CFA inhibition
of 98% by both samples.
exposed to either sample of sodium bisulfite for 20 hr did not resume
ability to form colonies during the study period of 9 days
authors concluded that sodium bisulphite may have neurotoxicity of
potential clinical significance because it is used as antioxidant in
commercial solutions of chloroprocaine.
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