Registration Dossier
Registration Dossier
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EC number: 222-037-3 | CAS number: 3323-53-3
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- GLP compliance:
- yes
- Test organisms (species):
- Daphnia magna
- Test type:
- semi-static
- Water media type:
- freshwater
- Total exposure duration:
- 21 d
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 4.2 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- > 4.2 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- GLP compliance:
- yes
- Test organisms (species):
- Daphnia magna
- Test type:
- semi-static
- Water media type:
- freshwater
- Total exposure duration:
- 21 d
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 6.3 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- 18 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
Referenceopen allclose all
Description of key information
NOEC Hexamethylendiamine (CAS: 124-09-4) = 4.2 mg/l
NOEC Adipic acid (CAS: 124-04-9) = 6.3 mg/l
Key value for chemical safety assessment
Additional information
There are no data on the chronic toxicity of AH-salt to aquatic invertebrates available. However, due to the rapid dissociation of AH-salt in water to
Adipic acid (CAS: 124-04-9) and Hexamethylendiamine (CAS: 124 -09 -4), it is appropiate to consider data on the dissociation products for the assessment of chronic toxicity. For both substances, chronic toxicity tests on Daphnia magna were performed by the Ministry of the Environment Japan (MOE 1997, 2002). The tests were performed according to OECD guideline 211 under GLP conditions. No observed effect concentrations (NOECreproduction) of 6.3 and 4.2 mg/l were determined for Adipic acid (CAS: 124 -04 -9) and Hexamethylendiamine (CAS: 124 -09 -4), underlining the little hazard potential of AH-salt towards aquatic organisms. The lower NOEC of 4.2 mg/l for Hexamethylendiamine was used for the derivation of PNECaqua.
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