Registration Dossier

Guidance on Safe Use

Guidance on Safe Use

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Administrative data

First-aid measures

Eye contact : Immediately flush eyes with plenty of water for at least 15 minutes, keeping eyelids open. Check for and remove any contact lenses. Get medical attention immediately. Chemical burns must be treated promptly by a physician.
Inhalation : Get medical attention immediately. Call a poison center or physician. If not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen by trained personnel. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation.
If inhaled, remove to fresh air. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband. In case of inhalation of decomposition products in a fire, symptoms may be delayed. The exposed p
erson may need to be kept under medical surveillance for 48 hours.
Skin contact : Get medical attention immediately. Call a poison center or physician. Flush contaminated skin with plenty of water. Remove contaminated clothing and shoes. Wash contaminated clothing thoroughly with water before removing it, or wear gloves. Continue to rinse for at least 10 mi
nutes. Chemical burns must be treated promptly by a physician.
Ingestion : As this product is a gas, refer to the inhalation section. Do not induce vomiting unless directed to do so by medical personnel.
Protection of first-aiders : No action shall be taken involving any personal risk or without suitable training. If it is suspected that fumes are still present, the rescuer should wear an appropriate mask or self-contained breathing apparatus. It may be dangerous to the person providing aid to give mouthto-
mouth resuscitation. Wash contaminated clothing thoroughly with water before removing it, or wear gloves.
Most important symptoms and effects, both acute and delayed Potential acute health effects Eye contact : Causes serious eye damage.
Inhalation : Fatal if inhaled. Exposure to decomposition products may cause a health hazard. Serious effects may be delayed following exposure.
Skin contact : Causes severe burns.
Ingestion : May cause burns to mouth, throat and stomach. As this product is a gas, refer to the inhalation section.
Over-exposure signs/symptoms
Eye contact : Adverse symptoms may include the following: pain, watering, redness
Inhalation : Adverse symptoms may include the following: wheezing and breathing difficulties, asthma, reduced fetal weight, increase in fetal deaths, skeletal malformations
Skin contact : Adverse symptoms may include the following: pain or irritation, redness, blistering may occur
Ingestion : No specific data.
Indication of any immediate medical attention and special treatment needed
Notes to physician : Treat symptomatically. Contact poison treatment specialist immediately if large quantities have been ingested or inhaled. In case of inhalation of decomposition products in a fire, symptoms may be delayed. The exposed person may need to be kept under medical surveillance for
48 hours.
Specific treatments : No specific treatment.

Fire-fighting measures

Extinguishing media
Suitable extinguishing media : In case of fire, allow gas to burn if flow cannot be shut off immediately.
Use an extinguishing agent suitable for the surrounding fire. Apply water from a safe distance to cool container and protect surrounding area.
Unsuitable extinguishing media : None identified.
Special hazards arising from the substance or mixture
Hazards from the substance or mixture : Contains gas under pressure. Oxidizing material. This material increases the risk of fire and may aid combustion.
Contact with combustible material may cause fire. In a fire or if heated, a pressure increase will occur and the container may burst or explode.
Hazardous thermal decomposition products :
Decomposition products may include the following materials: nitrogen oxides.
Avoid breathing dusts, vapors or fumes from burning materials.
In case of inhalation of decomposition products in a fire, symptoms may be delayed.
Advice for firefighters
Special precautions for firefighters: Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training. Contact supplier immediately for specialist advice. Move containers from fire area if
this can be done without risk. Use water spray to keep fire-exposed containers cool. If involved in fire, shut off flow immediately if it can be done without risk.
Special protective equipment for fire-fighters : Fire-fighters should wear appropriate protective equipment and self-contained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode. Clothing for fire-fighters (including helmets, protective boots and gloves) conforming
to European standard EN 469 will provide a basic level of protection for chemical incidents.
Additional information : None.

Accidental release measures

Personal precautions, protective equipment and emergency procedures
For non-emergency personnel : No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Shut off all ignition sources. No flares, smoking or flames in hazard area. Do not breathegas. Provide adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Put on appropriate personal protective equipment.
For emergency responders : If specialised clothing is required to deal with the spillage, take note of any information in "Exposure control/personal protection" section on suitable and unsuitable materials. See also the information in "For non-emergency personnel".
Environmental precautions : Ensure emergency procedures to deal with accidental gas releases are in place to avoid contamination of the environment. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air).
Methods and materials for containment and cleaning up
Small spill : Immediately contact emergency personnel. Stop leak if without risk.
Large spill : Immediately contact emergency personnel. Stop leak if without risk.
Reference to other sections : See "Exposure controls/personal protection" for information on appropriate personal protective equipment. See "Disposal considerations" for additional waste treatment information

Handling and storage

The information in this section contains generic advice and guidance. The list of Identified Uses should be consulted for any available use-specific information provided in the Exposure Scenario(s).
Precautions for safe handling
Protective measures : Put on appropriate personal protective equipment (see Exposure controls/personal protection section). Contains gas under pressure. Avoid exposure - obtain special instructions before use. Avoid exposure during pregnancy. Do not handle until all safety precautions have been read and understood. Do not get in eyes or on skin or clothing. Do not breathe gas. Use only with adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Keep away from clothing, incompatible materials and combustible materials. Keep reduction valves free from grease
and oil. Empty containers retain product residue and can be hazardous. Do not puncture or incinerate container.
Advice on general occupational hygiene : Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed. Workers should wash hands and face before eating, drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. See also Exposure controls/personal protection section for additional information on hygiene measures.
Conditions for safe storage, including any incompatibilities
Recommendations : Store in accordance with local regulations. Store in a segregated and approved area. Store away from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see Stability and reactivity section). Store locked up.Separate from reducing agents and
combustible materials. Keep container tightly closed and sealed until ready for use.
Seveso II Directive - Reporting thresholds
Danger criteria
Category_______________________ Notification and MAPP threshold_______Safety report threshold
H1 : Acute toxicity 1_____________________5 t_____________________________20 t
P4: Oxidizing gases_____________________50 t____________________________200 t
C1: Very toxic__________________________5 t_____________________________20 t
C3: Oxidizing__________________________50 t____________________________200 t

Transport information

Land transport (ADR/RID)

UN number:
1067
Shippingopen allclose all
Class:
2 (5.1, 8)
Labels:
2.3, 5.1, 8
SpecialProvisionsopen allclose all

Inland waterway transport (ADN(R))

UN number:
1067
Shippingopen allclose all
Class:
2, (5.1, 8)
Labels:
2.3, (5.1, 8)
Remarksopen allclose all

Marine transport (IMDG)

UN number:
1067
Proper shipping name and description:
NITROGEN DIOXIDE (Dinitrogen tetraoxide, )
Chemical name:
Dinitrogen tetraoxide
Class:
2.3 (5.1, 8)
EmS code:
F-C, S-W
Labels:
2.3 (5.1, 8)
Remarksopen allclose all

Air transport ICAO/IATA

UN number:
1067
Proper shipping name and description:
Nitrogen dioxide (dinitrogen tetraoxide, )
Chemical name:
Dinitrogen tetraoxide
Class:
2.3 (5.1, 8)
Labels:
2.3, (5.1, 8)
Remarksopen allclose all

Additional transport information

Additional transport information
ADR/DID Limited quantity : LQ0 Tunnel code : (C/D)
IATA Passenger and Cargo Aircraft Quantity limitation 0.0 Cargo Aircraft Quantity limitation 0.0

Exposure controls / personal protection

The information in this section contains generic advice and guidance. The list of Identified Uses should be consulted for any available use-specific information provided in the Exposure Scenario(s).
Control parameters
Occupational exposure limits : No exposure limit value known.
Recommended monitoring procedures : If this product contains ingredients with exposure limits, personal, workplace atmosphere or biological monitoring may be required to determine the effectiveness of the ventilation or other control measures and/or the necessity to use respiratory protective equipment.
Reference should be made to monitoring standards, such as the following: European Standard EN 689 (Workplace atmospheres - Guidance for the assessment of exposure by inhalation to chemical agents for comparison with limit values and measurement strategy) European Standard EN 14042
(Workplace atmospheres - Guide for the application and use of procedures for the assessment of exposure to chemical and biological agents) European Standard EN 482 (Workplace atmospheres - General requirements for the performance of procedures for the measurement of chemical agents)
Reference to national guidance documents for methods for the determination of hazardous substances will also be required.
Exposure controls
Appropriate engineering controls : Use only with adequate ventilation. Use process enclosures, local exhaust ventilation or other engineering controls to keep worker exposure to airborne contaminants below any recommended or statutory limits.
Individual protection measures
Hygiene measures : A washing facility or water for eye and skin cleaning purposes should be present.
Eye/face protection : Safety eyewear complying with an approved standard should be used when a risk assessment indicates this is necessary to avoid exposure to liquid splashes, mists, gases or dusts. If contact is possible, the following protection should be worn, unless the assessment indicates a higher degree of protection: chemical splash goggles and/or face shield. If inhalation hazards exist, a full-face respirator may be required instead. Tightly-fitting goggles CEN: EN136 face shield.
Skin protection
Hand protection : Chemical-resistant, impervious gloves complying with an approved standard should be worn at all times when handling chemical products if a risk assessment indicates this is necessary. Considering the parameters specified by the glove manufacturer, check during use that the gloves are still retaining their protective properties. It should be noted that the time to breakthrough for any glove material may be different for different glove manufacturers. > 8 h hours (breakthrough time) :
Protective gloves should be worn under normal conditions of use, neoprene and viton, CEN: EN374.
Body protection : Personal protective equipment for the body should be selected based on the task being performed and the risks involved.
Other skin protection : Appropriate footwear and any additional skin protection measures should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product.
Respiratory protection : Use a properly fitted, air-purifying or air-fed respirator or respiratory mask with acid gas filter type E complying with an approved standard if a risk assessment indicates this is necessary. Respirator selection must be based on known or anticipated exposure levels, the hazards of the product and the safe working limits of the selected respirator.
Environmental exposure controls : Emissions from ventilation or work process equipment should be checked to ensure they comply with the requirements of environmental protection legislation. In some cases, fume scrubbers, filters or engineering modifications to the process equipment will be necessary to reduce emissions to acceptable level.

Stability and reactivity

Reactivity : No specific test data related to reactivity available for this product or its ingredients.
Chemical stability : The product is stable.
Possibility of hazardous reactions : Hazardous reactions or instability may occur under certain conditions of storage or use.
Conditions may include the following: contact with combustible materials. Reactions may include the following: risk of causing fire.
Conditions to avoid : No specific data.
Incompatible materials : Highly reactive (can react in an explosive way) with liquid hydrocarbons, nitrobenzene, olefins, chlorine compounds and more in general with reducants and combustible materials.
Metals are not usually attacked by nitrogen oxides when in rigorously anhydrous and inert atmosphere, with exception of dinitrogen tetraoxide with copper and its alloys.
In presence of moisture, nitrogen oxides are very agressive towards many metals at ambient temperature.
Hazardous decomposition products : Under normal conditions of storage and use, hazardous decomposition products should not be produced.

Disposal considerations

The information in this section contains generic advice and guidance. The list of Identified Uses should be consulted for any available use-specific information provided in the Exposure Scenario(s).
Waste treatment methods
Product
Methods of disposal : The generation of waste should be avoided or minimized wherever possible. Disposal of this product, solutions and any by-products should at all times comply with the requirements of environmental protection and waste disposal legislation and any regional local authority requirements. Dispose of surplus and non-recyclable products via a licensed waste disposal contractor. Waste should not be disposed of untreated to the sewer unless fully compliant with the requirements of all authorities with jurisdiction.
Hazardous waste : The classification of the product may meet the criteria for a hazardous waste.
Packaging
Methods of disposal : The generation of waste should be avoided or minimized wherever possible.
Empty pressure vessels should be returned to the supplier. Waste packaging should be recycled.
Incineration or landfill should only be considered when recycling is not feasible.
Special precautions : This material and its container must be disposed of in a safe way. Empty containers or liners may retain some product residues. Do not puncture or incinerate container.