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EC number: 201-201-8
CAS number: 79-38-9
the Walther H.et al. (1970) study, mice were exposed to CTFE
concentration in air of 0.1, 0.3 and 0.8 % v/v (1000, 3000, 8000 ppm
v/v) for different exposure periods ranging in duration from 12 to 36
hours for the exposure level of 1000 ppm, from 2.5 to 16 hours for the
exposure level of 3000 ppm, from 1 to 4.25 hours for the exposure level
of 8000 ppm. Biochemical, optical, electron-microscopic and
enzyme-histochemical examinations were made.
on the results the authors distinguished three stages of lethality to
CTFE: the immediate lethality (which was originally named by the authors
“Acute lethality”) referred to lethality occurred during exposure, the
“follow-up lethality”, referred to lethality which corresponded closely
to the effects observed for acute lethality, “late lethality” indicating
a marked interval between exposure to CTFE and death.
the concentration of 1000 ppm, for an exposure period of 12 hours, the
lethality (follow-up and delayed) of 40% was observed. Immediate
lethality was observed when the exposure period was 16 hours, with a
total lethality of 60% (immediate, follow-up and delayed)
the concentration of 3000 ppm, for an exposure time of 4 hours, the
lethality (immediate, follow-up and delayed lethality) of 85 % was
the concentration of 8000 ppm, for an exposure period of 2,5 hours the
lethality of 100 % was observed (follow-up and delayed), when the
exposure period was 4,25 hours 100 % of immediate lethality was reported.
the lethality results, the LC50 (mouse, 4h) appears to be between 1000
ppm and 3000 ppm.
3000 ppm, after 30 min of exposure, damage on kidney ephytelium was
observed, attribyuted by the authors to damages on mitochondria
(enzyme-histochemical findings + increasing of ICDH blood level). Then,
a rapidly progressive necrotizing nephrosis was observed. Survival
animals showed regeneration of ephythelium within 6 days, (scar
formation in the kidney). Simultaneusly blood urea nitrogen, and
enzyme-hystochemical findings become normal.
to Walther Het al.,1970, the immediate and follow-up lethality of
CTFE should be attributed to, generalized damage of mitochondria which
affect kidneys, liver and myocardium. Necrosis
of myocardium was observed in the latter stage of the poisoning. The
"delayed" lethality was attributed to the prolonged and serious damage
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