Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

In accordance with column 2 of REACH (REGULATION (EC) No 1907/2006) Annex VIII the study on short term toxicity to fish (required in Section 9.1.3) does not need to be conducted as there are mitigating factors indicating that aquatic toxicity is unlikely to occur:
1. CTFE is expected to rapidly partition to atmosphere.
2. CTFE is not expected to partition to water.
The explanations supporting the above mitigating factors are the following:
The Guidance on Information Requirements and Chemical Safety Assessment Chapter R.7a: Endpoint Specific Guidance, Appendix R.7.1-4 indicates that substances with a Henry's Law constant of around 1 hPa m3/mole rapidly volatilise from water. On the basis of a Henry’s Law constant of 31,500 Pa m3/mol (HENRYWIN v3.20, EPISUITE v1.00), a vapour pressure of 612 kPa at 25°C (ISCS No. 0685, NIOSH) and a moderate water solubility (the water solubility value of 380 mg/l has been evaluated in a closed system with the atmosphere saturated of CTFE hence it represents an overestimation of the actual water solubility of CTFE in the natural system), CTFE is expected to primarily and rapidly partition to the atmosphere.
The EQC Fugacity III Model (Version 2.02, The Canadian Centre for Environmental Modelling and Chemistry, May 2003) confirms that all the CTFE released to atmosphere remains in this compartment. The model was run assuming emission only to air. In case of an accidental emission, CTFE is only released to atmosphere, because CTFE is a volatile gas at ambient conditions with a boiling point ranging from -26.2°C to -26.8°C . Therefore, CTFE would not be expected to partition into water.

Key value for chemical safety assessment

Additional information

CTFE is a volatile gas at ambient conditions with a boiling point in the range of -26.2°C (The Beilstein database. Reference: Miller - 1951 ) to -26.8°C (The Beilstein database. Reference: Henne - 1948), in addition, in case of accidental emission, it is released only to air compartment as indicated from the EQC Fugacity III Model (v.2.02, The Canadian Centre for Environmental Modelling and Chemistry, May 2003).

On the basis of its Henry's Law constant of 31,500 P m^3/mol (HENRYWIN v3.20, EPISUITE v1.00), its vapour pressure of 612 KPa at 25°C (NIOSH, ICSC No.0685) and a moderate water solubility, it is expected that CTFE rapidly volatilizes from water.

The value of water solubility of 380 mg/l was experimentally determined in a completely sealed system with an atmosphere saturated with CTFE. Althoughthe value of 380 mg/l itself reveals a moderate water solubility, it represents an overestimation of the actual water solubility of CTFE in the natural system since the experimental conditions did not represent the natural conditions.

The Henry’s Law constant of CTFE was calculated to be 31.500 Pa m3/mol (HENRYWIN v3.20, EPI Suite v4.0), suggesting that the substance is expected to rapidly volatilise from water to the air in fact the Guidance on Information Requirements and Chemical Safety Assessment Chapter R.7a: Endpoint Specific Guidance, Appendix R.7.1-4 indicates that substances with a Henry's Law constant of around 1 hPa m3/mole will rapidly volatilise from water; on the basis of the properties of CTFE it is expected that the substance primarily and rapidly partition to the atmosphere.

Hence, due to the gaseous nature of the substance and its partition to the atmosphere, as well as the consequent difficulty to appropriately test CTFE and provide meaningful results, no experimental aquatic toxicity data are reported. However, in order to evaluate the aquatic hazard profile of CTFE despite the fact that it is expected to rapidly partition to the atmosphere compartment, the results of the ECOSAR model ( v.1.00, EPI Suite v 4.0) may be applied.

The ECOSAR estimation for acute toxicity for fish is: 96h LC50 = 49.473 mg/L, however due to the low coefficient of determination resulting from the dataset of substances for the ECOSAR class of chemicals including CTFE, the result is not considered reliable.