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EC number: 201-201-8
CAS number: 79-38-9
In accordance with column 2 of REACH (REGULATION (EC) No 1907/2006) Annex VIII the study on short term toxicity to fish (required in Section 9.1.3) does not need to be conducted as there are mitigating factors indicating that aquatic toxicity is unlikely to occur:1. CTFE is expected to rapidly partition to atmosphere.2. CTFE is not expected to partition to water. The explanations supporting the above mitigating factors are the following:The Guidance on Information Requirements and Chemical Safety Assessment Chapter R.7a: Endpoint Specific Guidance, Appendix R.7.1-4 indicates that substances with a Henry's Law constant of around 1 hPa m3/mole rapidly volatilise from water. On the basis of a Henry’s Law constant of 31,500 Pa m3/mol (HENRYWIN v3.20, EPISUITE v1.00), a vapour pressure of 612 kPa at 25°C (ISCS No. 0685, NIOSH) and a moderate water solubility (the water solubility value of 380 mg/l has been evaluated in a closed system with the atmosphere saturated of CTFE hence it represents an overestimation of the actual water solubility of CTFE in the natural system), CTFE is expected to primarily and rapidly partition to the atmosphere.The EQC Fugacity III Model (Version 2.02, The Canadian Centre for Environmental Modelling and Chemistry, May 2003) confirms that all the CTFE released to atmosphere remains in this compartment. The model was run assuming emission only to air. In case of an accidental emission, CTFE is only released to atmosphere, because CTFE is a volatile gas at ambient conditions with a boiling point ranging from -26.2°C to -26.8°C . Therefore, CTFE would not be expected to partition into water.
CTFE is a volatile gas at ambient conditions with a boiling point in the
range of -26.2°C (The Beilstein database. Reference: Miller - 1951 ) to
-26.8°C (The Beilstein database. Reference: Henne - 1948), in addition,
in case of accidental emission, it is released only to air compartment
as indicated from the EQC Fugacity III Model (v.2.02, The Canadian
Centre for Environmental Modelling and Chemistry, May 2003).
On the basis of its Henry's Law constant of 31,500 P m^3/mol (HENRYWIN
v3.20, EPISUITE v1.00), its vapour pressure of 612 KPa at 25°C (NIOSH,
ICSC No.0685) and a moderate water solubility, it is expected that CTFE
rapidly volatilizes from water.
The value of water solubility of 380 mg/l was
experimentally determined in a completely sealed system with an
atmosphere saturated with CTFE. Althoughthe
value of 380 mg/l itself reveals a moderate water solubility, it
represents an overestimation of the actual water solubility of CTFE in
the natural system since the experimental conditions did not represent
the natural conditions.
The Henry’s Law constant
of CTFE was calculated to be 31.500 Pa m3/mol (HENRYWIN v3.20, EPI Suite
v4.0), suggesting that the substance is expected to rapidly volatilise
from water to the air in fact the
Guidance on Information Requirements and Chemical Safety Assessment
Chapter R.7a: Endpoint Specific Guidance, Appendix R.7.1-4 indicates
that substances with a Henry's Law constant of around 1 hPa m3/mole will
rapidly volatilise from water; on the basis of the properties of CTFE it
is expected that the substance primarily and rapidly partition to the
Hence, due to the gaseous nature of the substance and its partition to
the atmosphere, as well as the consequent difficulty to appropriately
test CTFE and provide meaningful results, no experimental aquatic
toxicity data are reported. However, in order to evaluate the aquatic
hazard profile of CTFE despite the fact that it is expected to rapidly
partition to the atmosphere compartment, the results of the ECOSAR model
( v.1.00, EPI Suite v 4.0) may be applied.
The ECOSAR estimation for acute toxicity for fish is: 96h LC50 = 49.473
mg/L, however due to the low coefficient of determination resulting from
the dataset of substances for the ECOSAR class of chemicals including
CTFE, the result is not considered reliable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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