Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-783-1 | CAS number: 126-33-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- No further information available.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Tetrahydrothiophene 1,1-dioxide
- EC Number:
- 204-783-1
- EC Name:
- Tetrahydrothiophene 1,1-dioxide
- Cas Number:
- 126-33-0
- Molecular formula:
- C4H8O2S
- IUPAC Name:
- 1λ⁶-thiolane-1,1-dione
- Reference substance name:
- Sulfolane
- IUPAC Name:
- Sulfolane
- Details on test material:
- - Name of test material (as cited in study report): Tetrahydrothiophene-1,1-dioxide
- Analytical purity: 95%
- Impurities: 5% water
- Supplied by Shin Nippon Rika, Lot No. 0007
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 5 weeks of age
- Weight at study initiation: 122-138 g for males; 107-120 g for females
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- No information is available.
- Doses:
- 892, 1204, 1626, 2195, 2963, and 4000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Each rat was weighed immediately prior to treatment, the day and thereafter 1, 3, 7 and 14 days after treatment. The rats were observed periodically during the two-week post-treatment observation period.
- Necropsy of survivors performed: yes - Statistics:
- LD50 was calculated by Van der Waerden method
Results and discussion
- Preliminary study:
- No information is available.
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 006 mg/kg bw
- Remarks on result:
- other: 1783 – 2256
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 130 mg/kg bw
- Remarks on result:
- other: 1844 - 2460
- Mortality:
- Males: 4/5, 5/5, and 5/5 at 2195, 2963, and 4000 mg/kg, respectively. Females: 3/5, 5/5, and 5/5 at 2195, 2963 and 4000 mg/kg, respectively.
- Clinical signs:
- other: Males at >/=1626 mg/kg: convulsions, decreased locomotor activity, ptosis, salivation, piloerection, chromodacryorrhea and perineal region soiling with urine. [CONFIRM THAT THESE EFFECTS REFER TO MALES] Females at >/= 1626 mg/kg: decreased locomotor act
- Gross pathology:
- Dead animals showed hemorrhagic black spots in their glandular stomach mucosa at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute oral LD50 in male and female rats were 2006 and 2130 mg/kg, respectively.
- Executive summary:
A single oral dose of sulfolane was administered to rats by gavage at doses of 0, 892, 1204, 1626, 2195, 2963, and 4000 mg/kg. The acute oral LD50 in male and female rats were established at 2006 and 2130 mg/kg, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
