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Ecotoxicological information

Long-term toxicity to fish

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Reference
Endpoint:
adult fish: sub(lethal) effects
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Data is from computational model developed by USEPA
Qualifier:
according to
Guideline:
other: Modeling database
Principles of method if other than guideline:
Estimation of 96 hr EC50 value of test chemical by modelling Database - ECOSAR v.1.11. The ECOSAR Class Program is a computerized version of the ECOSAR analysis procedures as currently practiced by the Office of Pollution Prevention and Toxics (OPPT). It has been developed within the regulatory constraints of the Toxic Substances Control Act (TSCA). It is a pragmatic approach to SAR. The structure-activity relationships (SARs) presented in this program are used to predict the aquatic toxicity of chemicals based on their similarity of structure to chemicals for which the aquatic toxicity has been previously measured. Most SAR calculations in the ECOSAR Class Program are based upon the octanol/water partition coefficient (Kow). Various surfactant SAR calculations are based upon the average length of carbon chains or the number of ethoxylate units
GLP compliance:
no
Analytical monitoring:
not required
Vehicle:
not specified
Test organisms (species):
other: Fish
Test type:
flow-through
Water media type:
freshwater
Total exposure duration:
28 d
Reference substance (positive control):
not specified
Key result
Duration:
28 d
Dose descriptor:
NOEC
Effect conc.:
6.867 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
growth rate
Remarks on result:
other: not toxic
Validity criteria fulfilled:
not specified
Conclusions:
Based on the prediction done using the EPI Suite ECOSAR, the long term toxicity on fish was predicted for test chemical. On the basis of effects observed in a flow through freshwater system, the effect concentration NOEC value for the substance is estimated to be 6.867 mg/l for Species for 28 days duration.
Executive summary:

Based on the prediction done using the EPI Suite ECOSAR, the long term toxicity on fish was predicted for test substance. On the basis of effects observed in a flow through freshwater system, the effect concentration NOEC value for the substance is estimated to be 6.867 mg/l for Species for 28 days duration. The test chemical is readily biodegradable it can be concluded that the test substance can be considered as non-toxic  to fish at environmentally relevant concentrations and can be considered as "not classified"  as per the CLP classification criteria.

Description of key information

Based on the prediction done using the EPI Suite ECOSAR, the long term toxicity fish was predicted for test chemical. On the basis of effects observed in a flow through freshwater system, the effect concentration NOEC value for the substance is estimated to be 6.867 mg/l for Species for 28 days duration.

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater fish:
6.867 mg/L

Additional information

Based on the prediction done using the EPI Suite ECOSAR, the long term toxicity on fish was predicted for test substance. On the basis of effects observed in a flow through freshwater system, the effect concentration NOEC value for the substance is estimated to be 6.867 mg/l for Species for 28 days duration. The test chemical is readily biodegradable it can be concluded that the test substance can be considered as non-toxic  to fish at environmentally relevant concentrations and can be considered as "not classified"  as per the CLP classification criteria.