Registration Dossier

Administrative data

Endpoint:
short-term repeated dose toxicity: inhalation
Type of information:
not specified
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Performance description is not in compliance with an actual guideline, result description is incomplete as e.g. individual animal results are not shown

Data source

Reference
Reference Type:
publication
Title:
On the toxicity of cyclohexylamine and dicyclohexylamine.
Author:
Lomonova GV
Year:
1963
Bibliographic source:
Gig. Tr. Prof. Zabol 7, 51-56.

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
no data
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not available

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Remarks on MMAD:
MMAD / GSD: No data
Analytical verification of doses or concentrations:
not specified
Details on analytical verification of doses or concentrations:
doses 0.11 mg/l/2 h
Duration of treatment / exposure:
30d
Frequency of treatment:
daily
No. of animals per sex per dose:
No data
Details on study design:
not available
Positive control:
no data

Examinations

Observations and examinations performed and frequency:
no data

Results and discussion

Effect levels

Dose descriptor:
other: not specified
Effect level:
ca. 0 other: not specified
Based on:
not specified
Sex:
not specified
Basis for effect level:
other: ability to swim

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

The exposure period was tolerated without visible clinical symptoms.
Post exposure, treated mice were able to swim as long as untreated control mice.

Applicant's summary and conclusion

Conclusions:
Inconclusive study, reliability 4, scarce data available
Executive summary:

30 day inhalation study in mice. Crucial information not available.

The exposure period was tolerated without visible clinical symptoms.
Post exposure, treated mice were able to swim as long as untreated control mice.