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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Study period:
1956
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Secondary source

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1956
Report Date:
1956
Reference Type:
secondary source
Title:
Final Report on the Safety Assessment of Squalane and Squalene
Author:
CIR Expert panel
Year:
1982
Bibliographic source:
International Journal of Toxicology 1982 1: 37

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Draize test
Deviations:
not specified
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
unchanged (no vehicle)
Controls:
yes, concurrent no treatment
Amount / concentration applied:
0.1 ml
Duration of treatment / exposure:
no data
Observation period (in vivo):
no data
Number of animals or in vitro replicates:
no data

Results and discussion

Any other information on results incl. tables

The compound did not produce irritation, despite the fact that no attempt was made to wash the eyes after instillation.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The compound did not produce irritation
Executive summary:

The procedure of Draize was used to test undiluted Squalene (0.1 ml) in the eyes of rabbits. The compound did not produce irritation, despite the fact that no attempt was made to wash the eyes after instillation.