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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Study period:
1978
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Secondary source

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1971
Reference Type:
secondary source
Title:
Final Report on the Safety Assessment of Squalane and Squalene
Author:
CIR Expert panel
Year:
1982
Bibliographic source:
International Journal of Toxicology 1982 1: 37

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: Draize test
Deviations:
not specified
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Squalane
IUPAC Name:
Squalane
Test material form:
other: liquid

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
clipped
Vehicle:
unchanged (no vehicle)
Controls:
yes, concurrent no treatment
Amount / concentration applied:
0.5 ml (undiluited)
Duration of treatment / exposure:
24 hours
Observation period:
no data
Number of animals:
3

Results and discussion

In vivo

Results
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Time point:
other: 24 h
Score:
ca. 0.29
Max. score:
8
Reversibility:
no data

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
According to the procedure of Draize, undiluted Squalene (0.5 ml) was applied to the clipped skin of three rabbits for 24 hours. The test material was practically nonirritating.
Executive summary:

According to the procedure of Draize, undiluted Squalene (0.5 ml) was applied to the clipped skin of three rabbits for 24 hours. The test material was practically nonirritating.