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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Study period:
1974
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Secondary source

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1974
Report Date:
1974
Reference Type:
secondary source
Title:
Final Report on the Safety Assessment of Squalane and Squalene
Author:
CIR Expert panel
Year:
1982
Bibliographic source:
International Journal of Toxicology 1982 1: 37

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Federal Hazardous Substances Act (FHSA
Deviations:
not specified
GLP compliance:
no
Test type:
fixed concentration procedure
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Strain: Sherman

Administration / exposure

Route of administration:
other: spray formulation
Type of inhalation exposure:
whole body
Vehicle:
not specified
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
ca. 1 h
Concentrations:
345 mg/L
No. of animals per sex per dose:
5 x sex x dose
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing:no data
- Necropsy of survivors performed: yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC0
Effect level:
ca. 9.1 other: mg/kg
Based on:
test mat.
Exp. duration:
1 h

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Autopsy 14 days after exposure revealed no abnormalities. LC0= 9.1 mg/kg bw
Executive summary:

The similar substance has been tested for acute inhalation toxicity on rats. The acute dose of 9.1 mg/kg doesen't show any abnormalities.