Registration Dossier
Registration Dossier
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EC number: 618-804-0 | CAS number: 919-94-8
Carcinogenicity
Administrative data
Description of key information
In accordance with column 2 of REACH Annex X, as TAEE is not considered mutagenic and as there is no evidence regarding hyperplasia induction and/or pre-neoplastic lesions from the subchronic repeated dose studies with the structure analogues TAME (2-methoxy-2-methylbutane) and ETBE (2-ethoxy-2-methylpropane), a carcinogenicity study is not needed for TAEE.
Key value for chemical safety assessment
Justification for classification or non-classification
Based on the negative results of the available in vitro genotoxicity studies with TAEE and the absence of evidence regarding hyperplasia induction and/or pre-neoplastic lesions from the subchronic repeated dose studies with the structure analogues TAME and ETBE, classification is not necessary for carcinogenicity in accordance with Directive 67/548/EEC and EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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