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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP-compliant study. Adequate for assessment.
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2003

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
Deviations:
no
Principles of method if other than guideline:
no data
GLP compliance:
yes

Test material

Constituent 1
Reference substance name:
CAN6
IUPAC Name:
CAN6
Test material form:
other: The test substance was moistened with sterile water in order to allow good contact between the test substance and the skin
Details on test material:
Appearance: White crystals.

Test animals

Species:
rabbit
Strain:
other: New Zealand Albino
Details on test animals or test system and environmental conditions:
Sex: Female.
Body weight: between 2.0 kg and 2.5 kg at the start of the experiment.
Feed and water were available ad libitum.

Test system

Type of coverage:
semiocclusive
Preparation of test site:
clipped
Vehicle:
other: The test substance was moistened with sterile water
Controls:
other: Adjacent surfaces of untreated skin served as a control for the trial.
Amount / concentration applied:
0.5 g of the substance was applied on the skin of the righi flank region.
Duration of treatment / exposure:
each animal received one patch far an exposure period of four hours.
Observation period:
One hour, 24 hours, 48 hours and 72 hours approximately after removal of the dressing, any skin lesions, which ha ve developed on the right flank of each animal, w ere evaluated.
Number of animals:
3
Details on study design:
no data

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Score:
0
Remarks on result:
other: The score is related to 1, 24, 48 and 72 hours.
Irritation parameter:
erythema score
Basis:
animal #2
Score:
0
Remarks on result:
other: The score is related to 1, 24, 48 and 72 hours.
Irritation parameter:
erythema score
Basis:
animal #3
Score:
0
Remarks on result:
other: The score is related to 1, 24, 48 and 72 hours.
Irritation parameter:
edema score
Basis:
animal #1
Score:
0
Remarks on result:
other: The score is related to 1, 24, 48 and 72 hours.
Irritation parameter:
edema score
Basis:
animal #2
Score:
0
Remarks on result:
other: The score is related to 1, 24, 48 and 72 hours.
Irritation parameter:
edema score
Basis:
animal #3
Score:
0
Remarks on result:
other: The score is related to 1, 24, 48 and 72 hours.
Irritant / corrosive response data:
no data
Other effects:
no other effects were observed.

Any other information on results incl. tables

no data

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Criteria used for interpretation of results: EU
Conclusions:
Under the experimental conditions adopted, the substance was found to be non irritant for the skin of the rabbit.
Executive summary:

Under the experimental conditions adopted, the substance was found to be non irritant for the skin of the rabbit.