Registration Dossier
Registration Dossier
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EC number: 604-138-8 | CAS number: 139481-59-7
Endpoint summary
Administrative data
Description of key information
Candesartan cilexetil is a pro-drug, it is extensively metabolised in the body to form the active drug
candesartan. Therefore, the active metabolite is expected to enter the environment following
patient use and candesartan is the focus of the environmental testing and risk assessment. Based on
the physical-chemical properties of candesartan, it is predicted to remain in the aqueous phase
during wastewater treatment and is unlikely to be removed via adsorption to sewage sludge solids.
Candesartan is not readily biodegradable. Once in the aquatic environment candesartan is
hydrolytically stable and the water-sediment transformation study showed little evidence of
degradation. The octanol-water partition coefficients, measured across the environmentally relevant
pH range, are low and candesartan is not predicted to bioaccumulate in aquatic organisms.
The substance did not show significant adsorption to sewage sludge (a Kd value was not determined).
Additional information
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