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EC number: 230-029-6 | CAS number: 6920-22-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26.9.1980-30.09.1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Pre OECD and pre-GLP study but well conducted according to draft OECD protocol.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Remarks:
- Draft guideline used of 1981 version
- GLP compliance:
- no
Test material
- Reference substance name:
- DL-hexane-1,2-diol
- EC Number:
- 230-029-6
- EC Name:
- DL-hexane-1,2-diol
- Cas Number:
- 6920-22-5
- Molecular formula:
- C6H14O2
- IUPAC Name:
- hexane-1,2-diol
- Reference substance name:
- 1,2-hexanediol
- IUPAC Name:
- 1,2-hexanediol
- Test material form:
- other: colourless liquid
- Details on test material:
- Purity > 97%
Density 0.95 g/ml
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- other: Russian Albino
- Details on test animals or test system and environmental conditions:
- 3 male and 3 female test animals were used, approx. 1 year of age. the animals were acclimized for 1 day. Animals were individually housed in stainless steel cages, receiving standardised food (Altromin) and water ad libitum. Room temperature was 22 ±1 °C and relative humidity 50-60% during the test period. A 12 hour light/12 hour dark period was maintained per day. cages were cleaned and desinfected prior to use.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- other: Traganth
- Controls:
- other: other areas on animal skin, treated equivalently but without test substance
- Amount / concentration applied:
- 0.5 ml test substance were suspended in 500 mg Traganth to ensure adsorption to skin without losses.
- Duration of treatment / exposure:
- 72 hours
- Observation period:
- observation period post exposure was scheduled for 14 days but was not required
- Number of animals:
- 3 female and 3 male
- Details on study design:
- both flanks of each animal were used, whereas the left side was exposed as is (clipped) and the right side clipped and artificially sacrifized at the skin surface avoiding bleeding and deeper skin lessions.
The test substance was applied for 4 hours and scores (according to Draize) were taken 1, 24, 48 and 72 hours following removal of the patches.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: intact skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: intact skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 48 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: intact skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: intact skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: sacrificed skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: sacrificed skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 48 h
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: sacrificed skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0.17
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: sacrificed skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: intact skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: intact skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 48 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: intact skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: intact skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: sacrificed skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: sacrificed skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 48 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: sacrificed skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: sacrificed skin
- Irritant / corrosive response data:
- A single application of 0.5 ml 1,2-hexanediol was tolerated almost without reaction. Only animals 1, 2 and 6 showed a defined erythrem 1 hour following removal of patches (score 2), which disappeared almost entirely at the end of the 72 hour observation period. Thus, the substance is considered non-irritant. Systemic toxic effects were not observed and animal behaviour was normal. The pure vehicle applied as control was tolerated without any reaction.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance 1,2-hexanediol is not irritating to rabbit skin.
- Executive summary:
A single application of 0.5 ml 1,2-hexanediol was tolerated almost without reaction. Only animals 1, 2 and 6 showed a defined erythrema 1 hour following removal of patches (score 2), which disappeared almost entirely at the end of the 72 hour observation period. Thus, the substance is considered non-irritant. Systemic toxic effects were not observed and animal behaviour was normal. The pure vehicle applied as control was tolerated without any reaction.
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