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EC number: 607-821-9
CAS number: 25858-24-6
In both experiments, no biologically
relevant increase in the rate of polyploid metaphases was found after
treatment with the test substance (0.0-0.2 %) as compared to the solvent
control values (0.0-0.2 %).
The positive controls showed distinct
increases in cells with structural chromosome aberrations.
The proliferation index of the lymphocytes
in solvent control cultures in the 22 hour preparation interval with and
without S9 mix (4 hour treatment; 1.02 and 1.51, respectively), in the
22 hours preparation interval without S9 mix (continuous treatment;
1.75), was checked by analyzing the proportion of mitotic cells in the
1st, 2nd, and 3rd metaphase (M1, M1 +, M2 and M3) indicating that the
lymphocytes divided about a 1.5 times within the early preparation
interval. This was also proven by the occurrence of sufficient numbers
of mitotic cells and by a clear clastogenicity observed after treatment
with the positive control substances.
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