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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
no data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Insufficient documentation for an assessment of reliability.
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1988
Report date:
1988

Materials and methods

Principles of method if other than guideline:
No data
GLP compliance:
not specified
Test type:
other: No data

Test material

Constituent 1
Chemical structure
Reference substance name:
(+-)-TRANS-3-METHYL-1-[(4-METHYLPHENYL)SULFONYL]-4-PHENYLPIPERIDINE-4-CARBONITRILE
Cas Number:
25858-24-6
Molecular formula:
C20H22N2O2S
IUPAC Name:
(+-)-TRANS-3-METHYL-1-[(4-METHYLPHENYL)SULFONYL]-4-PHENYLPIPERIDINE-4-CARBONITRILE
Details on test material:
No data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data
Doses:
640 mg/kg bw
No other concentrations mentioned
No. of animals per sex per dose:
No data
Control animals:
not specified
Details on study design:
No data
Statistics:
No data

Results and discussion

Preliminary study:
No data
Effect levels
Dose descriptor:
LD50
Effect level:
> 640 mg/kg bw
Mortality:
No data
Clinical signs:
No changes in behaviour and no toxic effects.
Body weight:
No data
Gross pathology:
No data
Other findings:
No data

Any other information on results incl. tables

Not applicable

Applicant's summary and conclusion

Conclusions:
The oral LD50-value of T000268 is > 640 mg/kg bw.
Executive summary:

Not applicable

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