Registration Dossier
Registration Dossier
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EC number: 215-246-6 | CAS number: 1314-87-0
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- chronic toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 928
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- In this paper we have made a comparative study of the effects upon rabbit of a series of different lead compounds, with the idea that such in formation may assist in elucidating the ultimate problem. The effect upon hemoglobin, he lethal dose, damage to the liver and kidney, and the effect upon the chorionic epithelium and upon the progeny have been considered.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Lead sulphide
- EC Number:
- 215-246-6
- EC Name:
- Lead sulphide
- Cas Number:
- 1314-87-0
- Molecular formula:
- PbS
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- unchanged (no vehicle)
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 11 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
8, 12 and 16 mg/kg
- No. of animals per sex per dose:
- 1
- Control animals:
- not specified
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Lead sulfide is a more insoluble salt than trilead phosphate. The toxicity experiments showed however that it is slightly injurious to the erythrocytes. There is probably a slow oxidation in the body to the sulfate which is considerably more soluble compound.
Applicant's summary and conclusion
- Conclusions:
- Lead sulphide was found slightly toxic in this study.
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