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Short-term toxicity to aquatic invertebrates

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Description of key information

EC50 (24 h) 1795 mg/L D. magna

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
1 795 mg/L

Additional information

No data on toxicity of trimagnesium dicitrate 3344 -18 -1 to aquatic invertebrates are available. A 24 h aquatic invertebrate study is, however, available for the parent acid of trimagnesium dicitrate, citric acid 77-92 -9 with D. magna in a neutralised solution. It is considered appropriate to read across the aquatic invertebrate results to trimagnesium dicitrate 3344 -18 -1 because under conditions relevant to ecotoxicity assessment, the trimagnesium salt of citric acid is expected to be fully dissociated. Trimagnesium dicitrate is not expected to contribute to the toxicity of the substance, being a ubiquitous element.

The study determines an LC50 value based on mortality of the test organism, by today's standards it is thought by the reviewer to be more accurate to refer to an EC50 value based on immobility, due to the difficulties is determining mortality of daphnids by visual inspection alone. Therefore a 24 h EC50 value of 1535 mg/L was determined for the effects of citric acid 77 -92 -9 on D. magna.

The resulting EC50 for citric acid is 1535 mg/L, which is equivalent to 1535 * 1.17 = 1795 mg/L of trimagnesium dicitrate.

using Mass of one mole of salt)/(mass of citric acid produced when the salts dissociates) = 451.1 / (2 * 192.9) = 1.17