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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
OECD guideline study, published in literature, minor restrictions in reporting, but otherwise adequate for assessment.
Qualifier:
according to
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
Deviations:
yes
Remarks:
Slight modifications
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
Daphnia magna
Test type:
semi-static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Details on test conditions:
TEST SYSTEM
The stock solutions were prepared fresh each day. The test solutions were renewed daily.

TEST MEDIUM / WATER PARAMETERS
- Detailed information about the chemical composition of the media is given elsewhere (Van Leeuwen and Maas, 1985).
Key result
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
0.24 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: 95% CL: 0.20-0.29

Description of key information

The 48-h EC50 of 0.24 mg/L in Daphnia magna is used in the assessment. 

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
0.24 mg/L

Additional information

Two short-term toxicity studies with Daphnia magna are available for zinc diethyldithiocarbamate. A non-GLP, OECD 202 guideline study is available (van Leeuwen et al., 1985a; van Leeuwen, 1986). The test is semi-static without analytical monitoring. The 48-h EC50 value is 0.24 mg/L in Daphnia magna.

 

Another study is a static GLP-compliant, EPA-660/3-75-009 guideline study without analytical monitoring (Analytical Bio-Chemistry Laboratories, Inc., 1983d). The 48-h EC50 value in Daphnia magna is 0.44 mg/L.

The 48-h EC50 of 0.24 mg/L is the most critical value and is therefore used for assessment.