Registration Dossier
Registration Dossier
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Reaction mass of 5-[(2R)-butan-2-yl]-2-[(1R,2R)-2,4-dimethylcyclohex-3-en-1-yl]-5-methyl-1,3-dioxane and 5-[(2R)-butan-2-yl]-2-[(1R,6R)-4,6-dimethylcyclohex-3-en-1-yl]-5-methyl-1,3-dioxane and 5-[(2S)-butan-2-yl]-2-[(1R,2R)-2,4-dimethylcyclohex-3-en-1-yl]-5-methyl-1,3-dioxane and 5-[(2S)-butan-2-yl]-2-[(1S,2R)-2,4-dimethylcyclohex-3-en-1-yl]-5-methyl-1,3-dioxane and 5-[(2S)-butan-2-yl]-2-[(1S,6R)-4,6-dimethylcyclohex-3-en-1-yl]-5-methyl-1,3-dioxane
EC number: 700-927-7 | CAS number: -
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
In a 48 h acute toxicity study, Daphnia magna were exposed to the substance according to OECD guideline Nr. 202 (1984) and in compliance with GLP principles. Daphnids were exposed to the following nominal concentrations: 0 (blank-control), Tween control, 0.32, 0.56, 1.0, 1.8, 3.2, 5.6 and 10 mg/L. The substance did not induce acute immobilization of Daphnia magna at and below 1.8 mg/L after 48 hours of exposure. The 48h-EC50 was determined as 5.35 mg/L (95% confidence interval between 4.53 and 6.98 mg/L) based on nominal concentrations. The present toxicity study is regarded as reliability 2, since nominal test concentrations were not confirmed analytically (true exposure concentrations are not known) and because the stated EC50 values are much exceeding the water solubility of the substance (0.6 mg/L). The physical effects can therefore not be distinguished from systemic effects.
In addition to this a short-term chronic (10 days) static renewal effluent toxicity test according to ASTM E729 with Ceriodaphnia dubia was found in the RIFM database, which was conducted to estimate the LC50 of 25 fragrance materials. For the substance a calculated LC50 of 0.35 mg/L was found.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 5.35 mg/L
Additional information
Awaiting the update of the IUCLID of the lead registrant the result is considered to be 5.35 mg/l. This does not influence the the C&L for Aurawood because its C&L is based on fish data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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