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EC number: 212-825-5
CAS number: 872-36-6
Developmental toxicity of vinylene carbonate was studied in rats
in dosed by oral gavage to 0, 15, 50 or 150 mg/kg bw/day for a minimum
of 28 days in a combined repeated dose toxicity study with
reproduction/developmental screening test according to OECD 422.
At 50 mg/kg bw/day, animals showed clinical signs, increased liver
weight (m), microscopic changes in liver (m), stomach (f) and thymus
(f), and deficiencies in maternal care.
At 150 mg/kg bw/day, animals showed clinical signs, decreased body
weight (gain), several haematological and clinical biochemistry changes,
stomach and liver abnormalities at macroscopic examination, increased
liver and kidney weights, microscopic changes in liver, stomach, thymus,
spleen, mesenteric lymph nodes (m/f) and mandibular lymph nodes (m).
High dose females showed a reduced number of living pups, a reduced
number of implantation sites and deficiencies in maternal care.
Based on the observed effects in mid and high dose animals, the
parental NOAEL was established to be 15 mg/kg bw/day.
In the absence of effects on pups, The NOAEL for developmental
toxicity was established to be at least 150 mg/kg bw/day.
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