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Toxicological information

Endpoint summary

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Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

Assessment for Contact Hypersensitivity to VC in the Mouse (Local Lymph Node Assay) was performed according to OECD 429. In the main study, three groups of five experimental animals were treated with test substance concentrations of 10%, 25% or 50% on three consecutive days, by open application on the ears. The SI values calculated for the substance concentrations 10 and 25% were 3.3 and 2.1 respectively, indicating that the test substance could elicit a SI>= 3. Based on these results, VC should be regarded as skin sensitizer.

Migrated from Short description of key information:

A reliable LLNA assay with VC is available.

Justification for selection of skin sensitisation endpoint:

reliable study on skin sensitisation

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

Based on the data available, VC needs to be classified as skin sensitizer (cat 1, H317) according to the:

-Globally Harmonized System of Classification and Labelling of Chemicals (GHS) of the United Nations (2011),

-Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures