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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1974
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: .

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974
Report date:
1974

Materials and methods

Principles of method if other than guideline:
Skin irritation/corrosion test
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Perhydroazepine
EC Number:
203-875-9
EC Name:
Perhydroazepine
Cas Number:
111-49-9
Molecular formula:
C6H13N
IUPAC Name:
azepane
Details on test material:
- Name of test material (as cited in study report): Hexamethylenimine
- Analytical purity: 98.18 %
- Lot/batch No.: Haskell No. 8588

Test animals

Species:
rabbit
Strain:
other: Albino
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 2-3 kg

Test system

Type of coverage:
occlusive
Preparation of test site:
other: clipped
Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
Duration of treatment / exposure:
4 h
Observation period:
48 h
Number of animals:
6
Details on study design:
TEST SITE
- Area of exposure: 1.5 x 1.5 inch

SCORING SYSTEM:
-Evaluation of skin reactions: immediately after removal of the patch and 24 and 48 h after initial application.

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Time point:
other: Corrosion was observed within the observation period of 48h
Score:
4
Max. score:
4
Reversibility:
not specified
Irritant / corrosive response data:
All six animals showed skin corrosion. (no further information given regarding time points, individual scores, reversibiliy).

Applicant's summary and conclusion

Interpretation of results:
Category 1 (corrosive)
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Under the applied test conditions the test substance induced skin corrosion in all six animals.
Executive summary:

A skin irritation/corrosion test was performed with six rabbits. The animals were exposed to 0.5 ml of test substance on the clipped skin under occlusive conditions for 4 h. The skin reactions were observed for 48 h after the initial exposure. All six animals showed skin corrosion.