Registration Dossier

Administrative data

Key value for chemical safety assessment

Additional information

In all in-vitro genetic toxicity assays (Ames test, CA, V79/HGPRT test), 1,4-bis[(2-ethyl-6-methylphenyl)amino]anthraquinone was negative.


Justification for selection of genetic toxicity endpoint
The results of the Ames tests, the chromosome aberration test and the HPRT test were considered

Short description of key information:
1,4-bis[(2-ethyl-6-methylphenyl)amino]anthraquinone, CAS 41611-76-1 was investigated in a Salmonella/microsome tests (Ames tests). Result: negative, no evidence of mutagenic activity was seen (with and without mutagenic activation). Additional, 1,4-bis[(2-ethyl-6-methylphenyl)amino]anthraquinone was evaluated as negative in an in-vitro MNT and also in a V79/HPRT test.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Due to the negative results in all available in-vitro genetic toxicity tests a classification is not justified.