Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 947-215-4 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14 October - 26 October 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- ca. 2.3
- Temp.:
- 35 °C
- pH:
- ca. 7
- Details on results:
- The chromatograms of Osyrol show one peak at an average retention time of 3.80 minutes, corresponding to a partition coefficient (log value) of 2.3.
- Conclusions:
- Partition coefficient (log Pow) = 2.3 at 35°C.
The substance has low potential to bioaccumulate in the environment, according to CLP classification criteria for aquatic chronic toxicity (log Kow < 4). - Executive summary:
The partition coefficient of the test substance was measured under GLP according to Guideline OECD 117/EU A8, HPLC method. The system was calibrated with 6 reference substances, and the result for the sample was interpolated from the linear regression.
Partition coefficient (log Pow) = 2.3 at 35°C.
Reference
References substances |
log Pow |
tR1 |
tR2 |
tRm |
k |
log k |
Thiourea |
|
2.580 |
2.586 |
2.58 |
|
|
Benzylalcohol |
1.1 |
2.934 |
2.938 |
2.94 |
0.137 |
-0.864 |
Benzene |
2.1 |
3.922 |
3.926 |
3.92 |
0.519 |
-0.285 |
Toluene |
2.7 |
4.682 |
4.686 |
4.68 |
0.813 |
-0.090 |
1 ,4-Dichlorobenzene |
3.4 |
5.586 |
5.591 |
5.59 |
1.164 |
0.066 |
Cumene |
3.7 |
6.482 |
6.486 |
6.48 |
1.510 |
0.179 |
1 2 4-Trichlorobenzene |
4.2 |
8.003 |
8.005 |
8.00 |
2.099 |
0.322 |
Capacity factor k = (tR/t0)-1
t0 : "dead time", i.e. retention time of thiourea
log Pow= a log k + b
Linear regression parameters :
Correlation coefficient r = 0.9814, a = 2.6347, b = 3.1617
Log Pow of the test substance was determined from its measured capacity factor.
Tested substance |
tR1 |
tR2 |
tRm |
k |
log k |
log Pow |
Osyrol |
3.801 |
3.798 |
3.80 |
0.4710 |
-0.327 |
2.3 |
Description of key information
The partition coefficient (log Pow) of 7-METHOXY-3,7-DIMETHYLOCTAN-2-OL MULTICONSTITUENT was determined to be 2.3 at 35°C.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.3
- at the temperature of:
- 35 °C
Additional information
The partition coefficient of the test substance was measured under GLP according to Guideline OECD 117/EU A8, HPLC method. The system was calibrated with 6 reference substances, and the result for the sample was interpolated from the linear regression.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
