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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 08 Jul - 10 Jul 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: Standard Concerning Testing Facility Relating to New Chemical Substances
- Version / remarks:
- March 31, 2011; No. 0331-8, Pharmaceutical and Food Safety Bureau, Ministry of Health, Labour and Welfare; March 29, 2011, No. 6, Manufacturing Industries Bureau, Ministry of Economy, Trade and Industry; No. 110331010, Environmental Policy Bureau, Ministry of the Environment, Japan.
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: control, 100 mg/L
- Sampling method: At the initiation of exposure: an aliquot of remaining unused test solution of each test group was taken; At the termination of exposure: an aliquot was taken from mid-depth of each replicate, without agitation (n = 1)
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: 0.0592 g of the test substance was weighed with the electronic balance. A stock solution was prepared by mixing the test substance with the dilution water to make a volume of 100 mL and then stirred for 48 h with a magnetic stirrer at 20 ± 1 °C. The test solution at 100 mg/L was prepared by diluting the whole volume of the stock solution with the dilution water to a volume of 500 mL.
- Eluate: no
- Differential loading: no
- Controls: yes, dilution water
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Source: National Institute for Environmental Studies, Japan
- Feeding during test: no
- Age at study initiation: < 24 h
ACCLIMATION
- Acclimation period: 14 d
- Acclimation conditions: the same as test
- Food type: Commercial condensed live Chlorella -V12 and commercial feed for fish (YCT, suspended yeast, dried alfalfa and Tetramin)
- Amount and frequency: 0.1 - 0.2 mg C (organic carbon)/ daphnid / day
- Health during acclimation: 0 % immobilisation; no abnormalitie were observed.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 250 mg CaCO3/L
- Test temperature:
- 20.0 - 20.1 °C
- pH:
- 7.9 - 8.0
- Dissolved oxygen:
- 8.2 - 8.6 mg/L
- Nominal and measured concentrations:
- nominal: control, 100 mg/L
measured: control, 105 mg/L - Details on test conditions:
- TEST SYSTEM
- Type: covered with lid
- Material, size, headspace, fill volume: glass, 100 mL, headspace: 0 mL, fill volume: 100 mL
- Aeration: none
- No. of organisms per vessel: 5
- No. of vessels per concentration: 4
- No. of vessels per control: 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: artificial reconstituted water, Elendt M4
- Culture medium different from test medium: no
- Intervals of water quality measurement: at initiation and termination of exposure
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 h light/8 hour dark
- Light intensity: Room lighting = 5.31 - 10.20 μE/m²/s (measured)
EFFECT PARAMETERS MEASURED:
- immoblization after 24 h and 48 h
RANGE-FINDING STUDY
- Test concentrations: 10 and 100 mg/L test substance
- Results used to determine the conditions for the definitive study: yes; no effects were observed in the range-finding study - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate (at 6-month intervals)
Results and discussion
Effect concentrations
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 105 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Cumulative immobilization of control: 0 %
- Results with reference substance (positive control):
- - Results with reference substance valid? yes
- EC50 (48 h) = 0.97 mg/L
- Historical EC50 (48 h) = 0.81 ± 0.12 mg/L (mean ± S.D., n = 25)
Any other information on results incl. tables
Table 1. Concentrations of the test substance in the test solutions
Nominal concentration of the test substance (mg/L) |
Measured concentration of the test substance (mg/L) |
||
0 h |
48 h |
mean |
|
Dilution water control |
< 0.15 #1 |
< 0.15 #1 |
- |
100 |
105 [105] |
105 [105] |
105 [105] |
[ ] : Percentage to the nominal concentration ( % )
#1: less than quantification limit
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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