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EC number: 810-418-2 | CAS number: 1703784-30-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04.2018 to 05.2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: SEPA (HJ/T 153-2004), The guidelines for testing of chemicals
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Version / remarks:
- (1992)
- Qualifier:
- according to guideline
- Guideline:
- other: Chemicals - Ready biodegradability - Manometric respirometry test (GB/T21801-2008)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Reaction products of acrylonitrile and 2,2’-Iminodi(ethylamine), hydrogenated
- EC Number:
- 810-418-2
- Cas Number:
- 1703784-30-8
- IUPAC Name:
- Reaction products of acrylonitrile and 2,2’-Iminodi(ethylamine), hydrogenated
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Lot number: 890000410422
Expiration date: 2018-08-02
Purity: 100%
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): A fresh sample of activated sludge from a domesticwast water treatment plant (Nanjing Chengdong Sewage Treatment Plant) was collected. (Batch No.: AS201804101)
- Laboratory culture: no
- Preparation of inoculum for exposure: The sludge was 3 times washed with basal mineral salt medium and aerated until use. Before use, the sludge was centrifuged one time (5000 r/min, 4°C, 10 minutes). Thereafter a small amount of the washed sludge was weighed and then dried at 100°C until the weight of the dried sludge did not change significantly anymore. Then the dry weight percentage of suspended solids (p) of the activated sludge was calculated to be 9.11%. Finally 22.0 g wet sludge after centrifugation was mixed with 0.5 L BSM to obtain an activated sludge with a mixed liquor suspended solids level of 4 g/L.
Amount of suspended solids: 30 mg/L - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 50 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: For the preparation of the stock solutions for mineral medium the following reagents (analytical grade) were used:
( a ) KH2PO4 8.50 g/L
K2HPO4 21.75 g/L
Na2HPO4 x 2 H2O 33.40 g/L
NH4Cl 0.50 g/L
pH 7.34 ± 0.2
( b ) CaCl2 x 2 H2O 27.50 g/L
( c ) MgSO4 x 7 H2O 22.50 g/L
( d ) FeCl3 x 6 H2O 0.25 g/L.
The mineral medium applied in the test contained 10 mL/L of mineral stock solution a and 1 mL/L of the mineral stock solution b–d, respectively.
- Additional substrate: no
- Solubilising agent (type and concentration if used): no
- Test temperature: 22 +/- 1°C
- pH: 6.40 ~ 7.36
- Aeration of dilution water: not reported
- Suspended solids concentration: 30 mg dry mass / L
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: respirometer
- Number of culture flasks/concentration: 2
- Method used to create aerobic conditions: activated sludge
- Measuring equipment: respirometer: Automatic respirometer (BOD meter)
- Test performed in closed vessels: yes
- Details of trap for CO2 and volatile organics if used: suitable absorbent used
SAMPLING
- Sampling method: oxygen uptake was measured
- Sample storage before analysis: no
CONTROL AND BLANK SYSTEM
- Inoculum blank: performed
- Toxicity control: performed
- Other: procedural control with reference substance performed
Reference substance
- Reference substance:
- aniline
Results and discussion
% Degradation
- Parameter:
- % degradation (O2 consumption)
- Value:
- 6.8
- Sampling time:
- 28 d
BOD5 / COD results
- Results with reference substance:
- The reference substance anilin was biodegraded by 74% within 14 d thus fulfilling the guideline criterion.
Any other information on results incl. tables
The biodegradation of Reaction products of acrylonitrile and 2,2’-Iminodi(ethylamine), hydrogenated in the static test was found to be at mean 6.8% for a concentration of 50 mg test item per liter after 28 days. With degradation rates below 10 % over the complete test duration no degradation rate within a 10-day-window can be calculated.
The degradation of the reference substance sodium benzoate had reached 74% within the first 14 days. The difference of extremes of replicate values of the removal of the test item at the end of the test is less than 20%. Therefore, the test can be considered as valid. No inhibitory effects of the test item were observed (more than 25% degradation occurred within 14 days) in the toxicity control.
Conclusion:
According to the guideline, Reaction products of acrylonitrile and 2,2’-Iminodi(ethylamine), hydrogenated must be considered as being not readily biodegradable under the test conditions applied.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- According to the guideline, PU-2017-793 must be considered as being not readily biodegradable under the test conditions applied.
- Executive summary:
The ready biodegradation of Neodecanoic acid, tin (2+) salt (2:1) was investigated in a study conducted according to OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test) and EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test) over a period of 28 days and using non-adapted activated sludge as inoculum. The biodegradation rate was determined by measurement of oxygen consumption. Inoculum blank, procedural/functional control with the reference substance sodium benzoate, and toxicity control using 100 mg/L test item and 100 mg/L reference compound were performed.
The biodegradation of Neodecanoic acid, tin (2+) salt (2:1) in the static test was found to be at mean 1% with a standard deviation of 1.1% for a concentration of 100 mg test item per liter and at mean 12% with a standard deviation of 9.2% for a concentration of 32 mg test item per liter after 28 days. However, with 14 % (SD = 9.2 %), the maximum mean degradation rate within the 28 day test duration was found in the 32 mg/L assays. For a concentration of 32 mg test item per liter, biodegradation within the 10-day-window was found to be 13%. The 10-day-window started at mean at day 15. With degradation rates below 10 % over the complete test duration in the 100 mg/L assays, no degradation rate within a 10-day-window can be calculated.
The degradation of the reference substance sodium benzoate had reached 90% within the first 14 days. The difference of extremes of replicate values of the removal of the test item at the end of the test for 100 mg/L and 32 mg/L, respectively, is less than 20%. Therefore, the test can be considered as valid. No inhibitory effects of the test item were observed (more than 25% degradation occurred within 14 days) in the toxicity control.
Conclusion:
According to the guideline, Neodecanoic acid, tin (2+) salt (2:1) must be considered as being not readily biodegradable under the test conditions applied.
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