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Diss Factsheets
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EC number: 695-745-7 | CAS number: 1079221-49-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
In-vitro skin penetration (OECD 428):
- Penetration through Human Dematomed Skin (in-vitro): 0.068% after 24 hours
- Mean total systemically available dose: 0.106% of the applied dose
Key value for chemical safety assessment
- Absorption rate - dermal (%):
- 0.106
Additional information
The test item was tested in an in vitro percutaneous penetration study through human dermatomed skin over 24 hours according to OECD TG guideline No. 428 (GLP, scored as validity 1 according to Klimisch criteria). The dose preparation (a typical oxidative hair dye formulation containing a nominal 4% test item which was mixed with peroxide developer (1:1 w/w)) was applied to the skin for 30 minutes to mimic in-use conditions. The mass balance and distribution of test item within the test system following the 24 hour run time was also determined.
The penetration process was monitored using [14C]-radiolabelled test item, which was incorporated into the formulation, prior to application. The receptor fluid was degassed phosphate buffered saline (PBS), in order to ensure that adequate sink conditions were maintained for this particular test material. The distribution of test item within the test system was measured and a 24 hour penetration profile was determined by collecting receptor fluid samples 0.5, 1, 2, 4, 8, 12, 16, 20 and 24 hours following application. The samples were analysed by liquid scintillation counting (LSC).
The results obtained in this study indicate that the test item at 2% in a typical oxidative hair dye formulation penetrated through human dermatomed skin at a very slow rate. The extent of test item penetration through human skin amounted to only 0.068% (0.272 ± 0.115 μg/cm2) of the applied dose, after 24 hours.
The mean total systemically available dose of test item (remaining epidermis plus dermis and receptor fluid) was 0.106% of the applied dose (corresponding to 0.422 μg/cm2).
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