Registration Dossier
Registration Dossier
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EC number: 616-059-6 | CAS number: 74191-85-8
Guidance on Safe Use
Administrative data
First-aid measures
- 4.1 Description of first aid measures
- General information
Symptoms of poisoning may even occur after several hours; therefore medical observation for at least 48
hours after the accident.
In case of irregular breathing or respiratory arrest provide artificial respiration.
- After inhalation Supply fresh air; consult doctor in case of symptoms.
- After skin contact Instantly wash with water and soap and rinse thoroughly.
- After eye contact
Rinse opened eye for several minutes (10 - 15) under running water. If symptoms persist, consult doctor.
- After swallowing
Rinse out mouth and then drink plenty of water (200 - 300 ml).
Administer medicinal carbon
Induce vomiting, only if person affected is fully conscious.
In case of persistent symptoms consult doctor.
- 4.2 Most important symptoms and effects, both acute and delayed
Disziness
Drowsiness/fatigue
Somnolence
Headache
Nausea
Decrease in blood pressure
Palpitation
- Information for doctor Pharmacological group: Alpha-1-receptor antagonist
- Danger
Danger of disturbed cardiac rhythm.
Danger of hypertension.
Danger of Hypotonie.
- 4.3 Indication of any immediate medical attention and special treatment needed
Keep patient in lying position.
Treatment of hypotension with fluid volume expansion.
Monitoring and/or support of the kidney function.
Give vasopressor if required.
Fire-fighting measures
- 5.1 Extinguishing media
- Suitable extinguishing agents
CO2, extinguishing powder or water jet. Fight larger fires with water jet or alcohol-resistant foam.
- For safety reasons unsuitable extinguishing agents Do not use a heavy water stream.
- 5.2 Special hazards arising from the substance or mixture
Formation of toxic gases is possible during heating or in case of fire.
Can be released in case of fire
Nitrogen oxides (NOx)
Carbon monoxide (CO), carbon dioxide (CO2)
Sulphur dioxide (SO2)
Risk of dust explosion
- 5.3 Advice for firefighters
- Protective equipment:
Wear self-contained breathing apparatus.
Do not inhale explosion gases or combustion gases.
Wear full protective suit.
- Additional information
Dispose of fire debris and contaminated fire fighting water in accordance with official regulations.
Accidental release measures
- 6.1 Personal precautions, protective equipment and emergency procedures
Wear protective equipment (described in section 8). Keep unprotected persons away.
Avoid causing dust.
Do not inhale dust.
Avoid contact with substance.
Ensure adequate ventilation
Keep away from ignition sources
- 6.2 Environmental precautions: Do not allow to enter drainage system, surface or ground water.
- 6.3 Methods and material for containment and cleaning up:
Collect mechanically.
Dispose of the material collected according to regulations.
Handling and storage
- 7.1 Precautions for safe handling
Store in cool, dry place in tightly closed containers.
Prevent formation of dust.
- Information about protection against explosions and fires:
Keep ignition sources away - Do not smoke.
Protect against electrostatic charges.
- 7.2 Conditions for safe storage, including any incompatibilities
- Storage
- Requirements to be met by storerooms and containers: No special requirements.
- Information about storage in one common storage facility: Not required.
- Further information about storage conditions:
Keep container tightly closed.
Protect from the effects of light.
Store container below 30 °C.
Transport information
Land transport (UN RTDG/ADR/RID)
- UN number:
- not applicable
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Exposure controls / personal protection
- 8.1 Control parameters
- Components with limit values that require monitoring at the workplace: Not required.
- DNELs (Derived no-effect level) No information available
- PNECs (predicted no effect concentration)
2.3 mg/l
No information available
- Additional information:
The lists that were valid during the compilation were used as basis.
OEL (Pfizer): 30 ug/m³ (TWA-8h)
- 8.2 Exposure controls
- Personal protective equipment
- General protective and hygienic measures
The usual precautionary measures should be adhered to general rules for handling chemicals.
Wash hands during breaks and at the end of the work.
- Breathing equipment: Not required.
- Protection of hands:
The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.
Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/
the chemical mixture.
Selection of the glove material on consideration of the penetration times, rates of diffusion and the
degradation
- Material of gloves
The selection of the suitable gloves does not only depend on the material, but also on further
marks of quality and varies from manufacturer to manufacturer.
- Penetration time of glove material
The exact break trough time has to be found out by the manufacturer of the protective gloves and has to be
observed.
- Eye protection:
Safety glasses
- Body protection: Protective work clothing.
Stability and reactivity
- 10.1 Reactivity No further relevant information available.
- 10.2 Chemical stability
- Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications.
- 10.3 Possibility of hazardous reactions
The product is not capable of dust explosion in the form supplied; enrichment with fine dust causes risk of
dust explosion
- 10.4 Conditions to avoid No further relevant information available.
- 10.5 Incompatible materials: No further relevant information available.
- 10.6 Hazardous decomposition products: No dangerous decomposition products known
Disposal considerations
- 13.1 Waste treatment methods
- Recommendation
Must not be disposed of together with household garbage. Do not allow product to reach sewage system.
- Uncleaned packagings:
- Recommendation:
Disposal must be made according to official regulations.
Packaging must be disposed of in compliance with country-specific regulations or must be passed to a
packaging return system.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
