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EC number: 500-236-9 | CAS number: 68920-66-1 1 - 2.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data based on the inhibition control of a ready biodegradability study.
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: 20 mg/L test item and 35 mg/L reference item were added directly to the test medium. - Test organisms (species):
- activated sludge
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): sewage plant at Hildesheim which comprises mostly municipal sewage and hardly industrial chemical waste.
- Pretreatment: The activated sludge was maintained in an aerobic condition by aeration for four hours and then homogenized with a mixer. The sludge was filtered and the fitrate (30 mL) was subsequently used to initiate inoculum.
- Initial cell/biomass concentration: Colony forming units in the test vessels: 10 exp 5 - 10 exp 6 CFU/L - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 14 d
- Test temperature:
- 20 - 24 °C
- Nominal and measured concentrations:
- Nominal test substance concentration: 20 mg/L
- Details on test conditions:
- EST CONDITIONS
- Composition of medium: Mineral nutrient solution according to OECD 301 B
- Test temperature: 20 - 24 °C
- pH: 7.59 - 7.93
TEST SYSTEM
- Culturing apparatus: 5000 mL test vessels (brown glass) filled with 3000 mL test medium
- Number of culture flasks/concentration: 2 - test item, 1 - toxic control, 2 - control
SAMPLING
- Sampling frequency: day 1, 4, 6, 8, 11, 14, 18, 21, 25, 28 and 29
CONTROL AND BLANK SYSTEM
- Inoculum blank: 2 replicates
- Reference control: 1 replicate
- Toxicity control: 1 replicate - Reference substance (positive control):
- yes
- Remarks:
- acetic acid, sodium salt
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 20 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: CO2 evolution
- Remarks:
- Result of toxicity control from ready biodegradability test
- Details on results:
- The toxicity control reached 73% biodegradation after 14 days and 87% after 28 days.
- Results with reference substance (positive control):
- “The reference material attained 87% degradation after 28 days
Reference
“If in a toxicity test, containing both the test and reference substance, less than 35% degradation (based on total DOC) or less than 25% (based on total ThOD or ThCO2) occurred within 14 days, the test substance can be assumed to be inhibitory.” (OECD guideline 301)
The degradation rate determined in the toxicity control was 73% aftter 14 days and thus the test substance is with high probability not toxic to aquatic microorganisms. The test item concentration in the toxicity control of 20 mg/L can be used as NOEC value for the toxicity to aquatic microorganisms.
Description of key information
The assessment of the toxicity of the target substance to microorganisms is based on the results of the toxicity control of the available biodegradation study. A NOEC(14 d): 20 mg/L (based on toxicity control of OECD 301 B) is used as key value for the CSA of the target substance .
Key value for chemical safety assessment
Additional information
The toxicity of the Ethoxylates (AE) category substances to microorganisms was assessed by read-across based on the grouping of substances (category approach). The available data were used for a general assessment of the toxicity of the Alcohol Ethoxylates (AE) category substances to microorganisms. Based on the available data adverse effects on microbial activity are not expected. The substances of the Alcohol Ethoxylates (AE) category are readily biodegradable. In all studies conducted with a toxicity control, no inhibition of the degradation process by the test substance was observed. The available studies investigating the respiration inhibition of activated sludge organisms and Pseudomonas putida determined no detrimental effects of the tested Alcohol Ethoxylates.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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