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Diss Factsheets
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EC number: 482-410-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 28 2009 to January 29 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodoological deficiencies, which do not affect the quality of relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Biodegradability Test of Chemical substances by Microorganisms (Yakushokuhatsu No. 1121002, Heisei 15.11.13 Seikyoku No.3, Kanpokihatsu No. 031121004, 21/11/03, revised 04/07/08)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Details on test material:
- Name of chemical substance: Hatcol 1760
CAs no: 156558-98-4
Purity: 99.2%
Lot number: A25983
Appearance: Colourless, clear, slightly viscous liquid
stability: Avoid high temperature, strong acid, strong base and strong oxidant.
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: Chemicals Evaluation and Research Institute, Japan
- Laboratory culture: Not applicable
- Method of cultivation: not applicable
- Storage conditions: not stated in report
- Storage length: not stated in report
- Preparation of inoculum for exposure: not stated in report
- Pretreatment: not stated in report
- Concentration of sludge:
Mixed liquor suspended solids: 3900 mg/l (BOD measurement), 3200 mg/l (Recovery test)
- Initial cell/biomass concentration: not stated in report
- Water filtered: not stated in report
- Type and size of filter used, if any: not stated in report - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimationopen allclose all
- Parameter followed for biodegradation estimation:
- DOC removal
- Parameter followed for biodegradation estimation:
- other: Biochemical oxygen demand - BOD
- Details on study design:
- TEST CONDITIONS
- Composition of medium:
Composition of liquids A,B, C and D
Liquid A: Aqueous solution containing 2.175% K2HPO4, 0.85% KH2PO4, 4.46% Na2HPO4.12H2O and 0.17% NH4Cl
Liquid B: Aqueous solution containing 2.25% MgSO4.7H2O
Liquid C: Aqueous solution containing 2.75% CaCl2
Liquid D: Aqueous solution containing 0.025% FeCl2.6H2O
- Additional substrate: not applicable
- Solubilising agent (type and concentration if used): not applicable
- Test temperature: 25 +/- 1°C
- pH: 7.0 =/- 0.04
- pH adjusted: yes - with 1N HCL or 1N NaOH.
- CEC (meq/100 g): not stated in report
- Suspended solids concentration: 3900 mg/l (BOD measurement), 3200 mg/l (Recovery test)
- Continuous darkness: not stated in report
TEST SYSTEM
- Culturing apparatus: closed system oxygen consumption measuring apparatus
- Number of culture flasks/concentration: three
- Method used to create aerobic conditions: not stated in report
- Method used to create anaerobic conditions: not applicable
- Measuring equipment: closed system oxygen consumption measuring apparatus
- Test performed in closed vessels: yes
- Test performed in open system: no
- Details of trap for CO2 and volatile organics if used: not applicable
SAMPLING
- Sampling frequency: At the start and end of exposure
- Sampling method: not stated in report
- Sterility check if applicable: not applicable
- Sample storage before analysis: not applicable
CONTROL AND BLANK SYSTEM
- Inoculum blank: 2.3 ml of activated sludge was added to the basal medium (The total volume of the basal medium and the sludge was held fixed at 300 ml)
- Abiotic sterile control: To 300 ml of purified water, 30.0 mg of the test substance was added
- Toxicity control/ activity control: To the basal medium, 29.5 µl (30.0 mg) of aniline and 2.3 ml of activated sludge was added
STATISTICAL METHODS:
Equations for calculation of degradability:
1) Degradability based on BOD:
Degradability (%) = ((BODs - BODb)/ThOD) x 100
where
BODs: Oxygen consumption (mg) in activity control and test suspensions
BODb: Oxygen consumption (mg) in inoculum blank
ThOD: Theoretical oxygen demand (mg) of aniline or the test substance ThOD
2) Degradability based on DOC
Degradability (%) = [1-(DOCs - DOCb) / DOCc] x 100
where
DOCs: DOC (mg) in test suspensions
DOCb: DOC (mg) in inoculum blank
DOCc: DOC (mg) in abiotic control
Reference substance
- Reference substance:
- aniline
Results and discussion
- Preliminary study:
- No preliminary study described in report.
- Test performance:
- The biodegradability test was judged valid since the measurement results fulfilled all the validity criteria of the guideline.
% Degradation
- Parameter:
- other: BOD
- Value:
- 59
- Sampling time:
- 28 d
- Remarks on result:
- other: The average biodegradability based on BOD.
- Details on results:
- The test substance is multicomponent esters of pentaerythritol and acids. Pentaerythritol and 3,5,5-trimethylhexanoic acid were detected as the transformation product. . Therefore, it is presumed that most of the ester bonds of the test substance were degraded. Linear carboxylic acids that construct the test substance have easily degradable structures. The average degradability based on BOD was 59%. It is considered that linear carboxylic acid is mineralised by sludge.
BOD5 / COD results
BOD5 / COD
- Parameter:
- BOD5
- Value:
- 59 other:
Any other information on results incl. tables
The average degradability based on BOD was 59%.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- other: Ready biodegradable when classified according to the Dangerous Preparations Directive (99/45/EEC)
- Conclusions:
- The substance did not achieve the required level of biodegradation within 28-days in order for it to be considered as readily biodegradable.
- Executive summary:
The study was conducted in accordance with the Test Method Relating to New Chemical Substances <Biodegradability Test of Chemical Substances by Microorganisms> (Yakushokuhatsu No. 1121002, Heisei 15.11.13 Seikyoku No. 2, Kanpokihatsu No. 031121002, November 21, 2003; the latest revision November 20, 2006).
The test substance was exposed to activated sludge in a closed-system oxygen consumption measuring apparatus. the biochemical oxygen demand (BOD) was measured over a 28 -day period. After this period, the amount of dissolved organic carbon (DOC) and the residual amount of test substance were measured. Reverse phase HPLC measurement was performed to confirm the existence of the transformation products, and the amount of assumed transformation products was measured. The biodegradability of the test substance was evaluated from these results.
From the degradability results based on the BOD (av. 59%), it is judged that the test substance is not readily biodegradable.
Although the analysis with the GPC column showed that 11 - 13% of the test substance remained, the test substance was not detected in the reversed phase HPLC measurement. Therefore it is considered that all the test substance disappeared and the component at the same retention time with the test substance was the transformation product.
The test substance is multicomponent esters of pentaerythritol and acids.
The average degradability based on BOD was 59%.
LC/MS was used to estimate the transformation products.
All the test substance disappeared, and 3,5,5 -trimethylhexanoic acid and pentaerythritol remained. It is judged that the test substance is not ready biodegradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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