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EC number: 310-079-6 | CAS number: 102242-48-8 The complex residue resulting from the vacuum distillation of C6-24 and C6-24 unsatd. fatty alcohols which is derived from hydrogenation of C6-24 and C6-24 unsatd. fatty acids methyl esters. It consists predominantly of satd. and unsatd. fatty alcohols having carbon numbers greater than C18, dimerization products, and long chain esters having carbon numbers greater than C32 and boils at > 250°C (482°F) at 10 torr.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
A skin irritation and an eye irritation study, both guideline studies, are available for the test item:
- Skin irritation study (Henkel R 9300103, 1993) with 3 rabbits, according to the OECD TG 404, GLP-conform.
- Eye irritation study (Henkel R 9300255, 1993) with 3 rabbit, according to the OECD TG 405, GLP-conform.
In addition, supporting information from an in vitro EpiDerm Skin Corrosion / Irritation Test (BASF 61V0276/12A161, 2012) and an in vitro HET-CAM assay with fertilized chicken eggs (Henkel R 9300036, 1993) are also available.
The findings of the OECD TG 404 skin irritation study indicated that the test item was irritating to the skin of rabbit. However, with respect to classification according to the EU Directive 67/548/EEC and to the CLP Regulation (EC) No. 1272/2008, the current criteria for classification are not fulfilled and thus, the substance has not to be classified as skin irritant. The results of an in vitro EpiDerm Skin Corrosion/Irritation Test, however, gave no indication for skin irritation. Thus, the test substance is considered non-irritating to the skin.
The findings of the OECD 405 eye irritation study gave no indication for eye irritation.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation
The test item was tested for skin irritation in 3 rabbits, under semi-occlusive conditions, according to the OECD TG 404 (Henkel R 9300103). After 4 h exposure, the animals were observed for up to 21 days, with the skin being examined for signs of irritation at the following reading time points: 1, 24, 48 and 72 h, day 7, day 14 and day 21. The skin findings were assessed by scoring according to the Draize scoring system.
At reading time point 1 h, all 3 animals displayed erythema and edema ranging from grade 1 to 2. After 24 hours, one animal displayed erythema and edema of grade 3, respectively and showed brownish discolouration; the 2 remaining animals had erythema and edema not exceeding grade 2 in severity, without any discolouration. At reading time point 48 h, the first animal still displayed skin reaction as described for 24 h. One of the 2 remaining animals showed erythema and edema of grade 1, respectively, whereas the second animal only showed erythema. At reading time point 72 h, the first animal still displayed skin reaction as described for 24 and 48 h. Both remaining animals showed erythema and edema of grade 1. After 7 days, no reversibility could be evidenced in any of the 3 animals. They all showed eschar formation and the first animal also showed a small shiny trip whereas another animal showed brownish discolouration. After 14 days, the first animal with the more severe findings still showed skin reaction as seen after 7 days, except for eschar. In contrast, full reversibility was achieved in the 2 remaining animals. After 21 days, the one animal with the more severe findings still showed erythema and edema graded 1, respectively, indicating that full reversibility was not achieved.
The mean erythema and edema scores from all 3 animals over the reading time points 24, 48 and 72 h which are relevant for assessment were 1.6 for erythema and 1.6 for edema. At day 14, full reversibility was achieved in 2/3 animals. Thus, the findings indicate that the test item was slightly irritating to the skin of the rabbits.
Supporting information from an in vitro EpiDerm Skin Corrosion/Irritation Test performed according to OECD guidelines 431 and 439 under GLP conditions (BASF 61V0276/12A161, 2012) is available. Reconstructed three dimensional human epidermis was treated with the undiluted test substance (85.1% pure) for 3 and 60 min (Corrosion test) or 60 min followed by a 42-h post-incubation period (Irritation test). To evaluate the skin irritating potential, cell viability was measured via an MTT assay and was expressed as percentage of the negative control (de-ionized water in the Corrosion test and PBS in the Irritation test).
In the Corrosion tests, two tissues per condition were analysed and 8 N KOH served as positive control. The mean cell viability after treatment with 50 µL of the test substance was 102% and 98% after 3 and 60 min, respectively. In the Irritation test, three tissues per condition were analysed and 5% SDS was used as positive control. The mean cell viability after treatment with 30 µL of the test substance was 98%. Thus, the test substance was neither corrosive nor irritant to the reconstructed human skin in this in vitro study.
Eye irritation
The test item was further tested for eye irritation in 3 rabbits, according to the OECD TG 405 (Henkel R 9300255). After 24 h exposure, the treated eyes were washed and the animals were observed for 72 hours, with the eyes being examined for signs of irritation at the following reading time points: 1, 24, 48 and 72 h. The findings were assessed by scoring according to the Draize scoring system.
Following treatment, the first test animal displayed erythema grade 1 accompanied by discharge grade 2 at reading time point 1 h only. The second animal showed no eye reaction at all, whereas the third one had discharge grade 2 at reading time point 1 h, and conjunctival redness at 24 h, respectively. Thus, the test item was not irritating to the eyes of the rabbits.
The test item was further subjected to the in vitro HET-CAM assay and was applied onto the chorioallantoic membrane of fertilized chicken eggs; Texapon ASV (5% a.i.) served for reference substance (Henkel R 9300036). In a pretest, the test material induced weak hemorrhage on the CAM after 200 seconds. In the main test, the irritation potential of the test item was determined as 0.00 whereas for the reference substance, it was 1.00. Thus, it was concluded that the undiluted test item is not corrosive.
Justification for classification or non-classification
Taking into account the available data, no classification according to the EU Directive 67/548/EEC and to the CLP Regulation (EC) No. 1272/2008 is warranted for "alcohols, C6 -C24 and C6 -C24 unsat., distn residues" (CAS 102242 -48 -8) regarding skin and eye irritation.
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