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EC number: 293-917-2 | CAS number: 91648-55-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- adult fish: sub(lethal) effects
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17 Nov - 01 Dec 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Justification for type of information:
- Refer to the Category Approach Justification document provided in IUCLID6 Section 13.
- Qualifier:
- according to guideline
- Guideline:
- other: UBA (German Federal Environmental Agency) - method: Prolonged toxicity test with zebra fish - Brachiodanio rerio
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 204 (Fish, Prolonged Toxicity Test: 14-day Study)
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: Stock solution of 1 g/L further diluted to final volumes. - Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: zebra fish
- Source: West Aquarium, delivery 30th April 1986
ACCLIMATION
- Type and amount of food: Altromin
- Health during acclimation (any mortality observed): <0.1% during last week before transfer to the test vessels
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 14 d
- Test temperature:
- 22.0 - 22.5 °C
- pH:
- 7.0 - 7.2
- Dissolved oxygen:
- 64 - 97%
- Nominal and measured concentrations:
- nominal: 0, 0.3, 1.0, 3.0, 10.0 and 30.0 mg of product/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 10 L glass aquaria containing 5 L testing solution
- Renewal rate of test solution: three times per week
- No. of organisms per vessel: 10
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Synthetic water
OTHER TEST CONDITIONS
- Photoperiod: 16 hours light/ 8 h dark
EFFECT PARAMETERS MEASURED: mortality
- Reference substance (positive control):
- no
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1.65 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- adult mortality
- Endpoint:
- adult fish: sub(lethal) effects
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Refer to the Category Approach Justification document provided in IUCLID6 Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Reference substance (positive control):
- no
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1.65 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- adult mortality
- Remarks on result:
- other: read-across from CAS 68955-20-4
Referenceopen allclose all
Table 1: Mortality of adult specimens in %:
Incubation time (in days) |
|||||||
Concentration [mg /L] |
0 |
2 |
4 |
7 |
9 |
11 |
14 |
Control |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0.30 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1.0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
3.0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
10 |
0 |
80 |
80 |
100 |
100 |
100 |
100 |
30 |
0 |
100 |
100 |
100 |
100 |
100 |
100 |
Description of key information
14d NOEC (Danio rerio) = 1.65 mg/L (UBA guideline equivalent to OECD 204, read-across)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1.65 mg/L
Additional information
Since no reliable long-term toxicity tests with fish are available for C16-20AS Na (CAS 91648-55-4), in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read-across to another structurally related substance was conducted. Read-across data available for C16-18AS Na (CAS 68955-20-4) were used considering animal welfare. Toxicity of alkyls sulfates is dependent on the carbon chain length. Homologues of C-chain length of C13 to C15 are considered as the most toxic from the whole Alkyl Sulfate Category. Toxicity of the chains from C16 and higher will decrease due to lower bioavailability as a consequence of reduced water solubility.
One non-GLP 14-day study with fish is available for C16-18AS Na (CAS 68955-20-4, BASF 2001). The test was performed according to a German UBA method for a prolonged toxicity test with zebra fish, equivalent to OECD 204 guideline. Zebrafish (Danio rerio) were exposed for 14 days under semi-static conditions to five test concentrations up to 30 mg/L of the test substance of 55% purity, corresponding to 16.5 mg a.i./L. No analytical measurements are available. The 14-day NOEC value was determined to be 1.65 mg a.i./L (nominal concentration). As the results show, mortality of fish occurred at the concentrations of 10 mg/L of product and higher (equal to 5.5 mg a.i./L). Fish mortality reaching 80% and more was seen already on day 2. On the other hand, no toxic effects are recorded at the concentration of 3 mg product/L (equal to 1.65 mg a.i./L) thoughout the whole testing period. Therefore, the reliable long term NOEC value for fish can be considered as 1.65 mg a.i./L.
Due to structure and property similarities with the tested category member it can be concluded that the above results apply also to C16-20AS Na (CAS 91648-55-4). The worst case NOEC value for fish is 1.65 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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