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Diss Factsheets
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EC number: 274-581-6 | CAS number: 70356-09-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Stability
Hydrolysis
Study on hydrolysis waived due to the extremely poor water solubility of the test item of 0.027 mg/L.
Biodegradation:
Biodegradation in water: screening tests
Both a study on anaerobic biodegradability and a study on (aerobic) inherent biodegradability revealed that the substance is not readily biodegradable. Based on ECHA Guidance "R.11 PBT Assessment", if the test item is not degradable in an inherent biodegradability study, the substance shall be considered as non biodegradable and further testing shall not be considered.
Ultimate degradation in surface water (OECD 309)
The half-life, DT50, of the parent compound in natural water at 12 °C was determined to be 10.8 days at high dose (0.015 mg/L) and 10.2 days at low dose (0.005 mg/L). Under sterile conditions the parent compound degraded slower than in a non-sterile conditions. The half-life at 12 °C was 54.7 days at a concentration of 0.015 mg/L. The parent compound degraded to two major metabolites, depending on the placement of the radiolabel and a common metabolite for both labels.
Biodegradation in sediment (OECD 308)
The half-life, DT50, of the parent compound in freshwater sediment was determined to be 111 days at 12 °C in a river water/sediment system. The half-life in the water phase was 0.13 days at 12 °C and from the entire river water/sediment system the DT50 was determined to be 72.1 days at 12 °C. Using a pond water/sediment system, the DT50 for the parent compound in the sediment phase was 139 days at 12 °C, for the pond water phase 1.4 days at 12 °C and for the entire pond water/sediment system, the DT50 was 99 days at 12 °C.
Bioaccumulation
Bioaccumulation: aquatic / sediment
In a dietary study according to OECD TG 305 under flow-through conditions with Oncorhynchus mykiss the lipid normalized BMF was calculated to be 0.1218. The half-life (DT 50) for elimination of BMDBM during the depuration phase was 3.83 days. The growth corrected rate constant K2 for depuration was calculated to be 0.1811. In compliance with the guidance document to OECD TG 305 (2nd draft, 2016) the kinetic BMF value obtained from the OECD 305 study was translated into BCF values by using the excel spreadsheet published by OECD (version 2, as provided on 10 December 2020). Based on the experimental data and current guidance the BCF of the test item is considered to be in the range between 2000 and 3000. An in-depth assessment on the bioaccumulation potential of the substance is attached to IUCLID section 13.2.
Transport and distribution
Adsorption/desorption
The computational approach (QSPR) for deriving the Koc is based on the real physical properties of the test item, i.e. the experimentally derived log Kow of 6.1. When using the geometric mean of the results of four different QSPR models, the resulting log Koc is 4.65 (Koc = 44242 L/kg). Based on this result BMDBM has to be considered as "immobile" in sediments or soil.
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