Registration Dossier
Registration Dossier
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EC number: 274-572-7 | CAS number: 70331-94-1
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics, other
- Remarks:
- Written assessment
- Type of information:
- other: Written assessment
- Adequacy of study:
- other information
- Study period:
- January 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Written assessment
- Justification for type of information:
- At the current level of registration, a written assessment is suitable.
- Objective of study:
- other: Written assessment of ADME
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Written assessment based on available study data.
- Details on absorption:
- See attached background material below.
- Details on distribution in tissues:
- See attached background material below.
- Details on excretion:
- See attached background material below.
- Details on metabolites:
- See attached background material below.
- Bioaccessibility (or Bioavailability) testing results:
- See attached background material below.
- Conclusions:
- In conclusion, there is evidence that the substance, could be readily absorbed on ingestion and metabolised quickly to amino acids, amines and ultimately oxidised to carbon dioxide and nitrogen compounds, with no ill effects noted.
Consequently, the substance is considered to have low bioaccumulation potential. - Executive summary:
In conclusion, there is evidence that the substance, could be readily absorbed on ingestion and metabolised quickly to amino acids, amines and ultimately oxidised to carbon dioxide and nitrogen compounds, with no ill effects noted.
Consequently, the substance is considered to have low bioaccumulation potential.
Reference
Description of key information
Written assesssment of toxicokinetics.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 100
- Absorption rate - inhalation (%):
- 100
Additional information
In conclusion, there is evidence that the substance, could be readily absorbed on ingestion and metabolised quickly to amino acids, amines and ultimately oxidised to carbon dioxide and nitrogen compounds, with no ill effects noted.
Consequently, the substance is considered to have low bioaccumulation potential.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
