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EC number: 271-865-1 | CAS number: 68610-44-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2012-10-04
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Principles of method if other than guideline:
- The substance has been mixed with double distilled water at different ratios in order to determine the water solubility.
- GLP compliance:
- no
- Type of method:
- other: See description below
- Water solubility:
- 760 g/L
- Temp.:
- 20 °C
- pH:
- ca. 7
- Remarks on result:
- other: pH was not adjusted.
- Conclusions:
- Interpretation of results (migrated information): very soluble (> 10000 mg/L)
The water solubility of the substance is determined to 760 g/L. - Executive summary:
The water solubility of the substance is determined to 760 g/L.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Specific details on test material used for the study:
- - Composition of test material: Sodium-2-ethylhexyliminomonopropionate and Sodium-2-ethylhexyliminodipropionate
- Analytical purity: >=98%
- Purity test date: 13 December 2017
- Lot/batch No.: WI6K21X06-FD2
- Expiration date of the lot/batch: 05 December 2018
- Appearance: White paste
- Storage: At room temperature - Key result
- Water solubility:
- >= 629 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 11
- Conclusions:
- The flask method was applied for the determination of the water solubility of the test item. The water solubility of the test item at 20°C was ≥ 629 g/L. The pH of the aqueous samples was 11.0.
- Executive summary:
The water solubility of the test item was determined in a GLP-compliant study performed in accordance with EU Method A.6 and OECD Guideline No. 105. The solubility in water of the test item was assessed to be ≥ 629 g/L at 20°C.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- March 09, 2018 - June 11, 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: OECD harmonized ring method
- Deviations:
- no
- Principles of method if other than guideline:
- The Critical Micelle Concentration (CMC) was determined by measuring the surface tension of test item solutions at different test item concentrations. The surface tension of the test item solutions was determined using the OECD harmonized ring method.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- other: OECD harmonized ring method
- Specific details on test material used for the study:
- - Composition of test material: Sodium-2-ethylhexyliminomonopropionate and Sodium-2-ethylhexyliminodipropionate
- Analytical purity: >=98%
- Purity test date: 13 December 2017
- Lot/batch No.: WI6K21X06-FD2
- Expiration date of the lot/batch: 05 December 2018
- Appearance: White paste
- Storage: At room temperature - Water solubility:
- 763 mg/L
- Conc. based on:
- other: surface tension
- Remarks on result:
- other: Critical Micelle Concentration (CMC)
- Conclusions:
- The Critical Micelle Concentration (CMC) of the test item was determined by measuring the surface tension of test item solutions at different test item concentrations. The CMC of the test item was 763 mg/L.
- Executive summary:
The Critical Micelle Concentration (CMC) of the test item was determined by measuring the surface tension of test item solutions at different test item concentrations, according to the OECD harmonized ring method. The CMC was 763 mg/L.
Referenceopen allclose all
Preliminary Test
> Results based on the response of Sodium-2-Ethylhexyliminopropionate (m/z 202.1)
The content of test item dissolved in the water sample was 388 g/L.
> Results based on the response of Sodium-2-Ethylhexyliminodipropionate (m/z 274.2)
The content of test item dissolved in the water sample was 383 g/L.
Main Study
> Results based on the response of Sodium-2-Ethylhexyliminopropionate (m/z 202.1)
The results for the samples taken at 24, 48 and 72 hours are given in the table below. The solubility is reported as greater than or equal to since the solutions were not saturated 5 times due to the nature of test item (gel is formed). The maximum difference of the concentrations determined in the 24, 48 and 72 hour test samples was ≤ 15%. Based on this, the water solubility of the test item is given as the mean value of the analyzed concentrations.
Stirring time [hours] |
Analyzed concentrations1 [g/L] |
Mean [g/L] |
Maximum difference [%] |
pH |
24 48 72 |
≥ 683 ≥ 640 ≥ 625 |
≥ 650 |
8.9 |
11.0 11.0 11.0 |
1 Extrapolated from response for m/z 202.1
> Results based on the response of Sodium-2-Ethylhexyliminodipropionate (m/z 274.2)
The results for the samples taken at 24, 48 and 72 hours are given in the table below. The solubility is reported as greater than or equal to since the solutions were not saturated 5 times due to the nature of test item (gel is formed). The maximum difference of the concentrations determined in the 24, 48 and 72 hour test samples was ≤ 15%. Based on this, the water solubility of the test item is given as the mean value of the analyzed concentrations.
Stirring time [hours] |
Analyzed concentrations2 [g/L] |
Mean [g/L] |
Maximum difference [%] |
pH |
24 48 72 |
≥ 663 ≥ 614 ≥ 611 |
≥ 629 |
8.2 |
11.0 11.0 11.0 |
2 Extrapolated from response for m/z 274.2
Overall Results
Based on the response (i.e. peak area) of Sodium-2-Ethylhexyliminopropionate (m/z 202.1), the water solubility of the test item as a whole is calculated to be ≥ 650 g/L. Based on the response of Sodium-2-Ethylhexyliminodipropionate (m/z 274.2), the water solubility of the test item as a whole is calculated to be ≥ 629 g/L. No matter which response was used for calculations (m/z 202.1 or m/z 274.2), the calculated water solubility values for the test item are consistent, indicating that the limit of solubility was not reached for any of the constituents. The water solubility of the test item at 20°C can be reported to be ≥ 629 g/L. According to the composition of the test item, it can be deduced that the water solubility of Sodium-2-Ethylhexyliminopropionate (m/z 202.1) at 20°C is ≥429 g/L (based on analytical composition) while the water solubility of Sodium-2-Ethylhexyliminodipropionate (m/z 274.2) at 20°C is ≥193 g/L (based on analytical composition).
Preliminary data
According to the preliminary data, an estimated CMC of 1340 mg/L was obtained.
Main study
The CMC was determined from the intersection of the two trend lines y1and y2. Trendline y1 was obtained using the data of the test solutions with test item concentrations of 100, 200, 500 and 700 mg/L. Trendline y2 was obtained from the mean surface tension of the test solutions with test item concentrations of 1000, 2000, 4000, 7000 and 10000 mg/L. The intersection was calculated to be at a log C value of 2.88. It corresponded with a CMC of 763 mg/L.
Description of key information
The water solubility of 2-Propenoic acid, methyl ester, reaction products with 2-ethyl-1-hexanamine and sodium hydroxide (methanol free) was determined in a GLP-compliant study performed in accordance with EU Method A.6 and OECD Guideline No. 105. The solubility in water of the test item was assessed to be ≥ 629 g/L at 20°C. Besides, as the test item was demonstrated to exhibit surface active properties, its Critical Micelle Concentration (CMC) was determined in a GLP-compliant study performed in accordance with the OECD harmonized ring method. The CMC was 763 mg/L.
Key value for chemical safety assessment
- Water solubility:
- 629 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of 2-Propenoic acid, methyl ester, reaction products with 2-ethyl-1-hexanamine and sodium hydroxide (methanol free) was determined in a GLP-compliant study performed in accordance with standard methods, without deviations. The study is considered as reliable (Klimisch 1) and is selected as a key study for the endpoint.
The Critical Micelle Concentration (CMC) of the test item was determined in a GLP-compliant study performed in accordance with standard methods, without deviations. The study is considered as reliable (Klimisch 1) and is selected as a supporting study for the endpoint.
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