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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 251-646-7 | CAS number: 33703-08-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 8.9 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 25
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 222.5 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- The NOAEL from the oral one-generation study was converted to an inhalation NOAEC according to the following formula. NOAEC = NOAEL / resp. volume (rat) x (resp. volume (human) / resp. volume (human, light activity)) x (absorption (oral) / absorption (inhal.)) = 170mg/kg b.w. / 0.384 m³/kg b.w. x 0.67 x 0.75 / 1 = 222.5 mg/m³. Based on toxicokinetic data absorption was considered to be 75% after oral exposure and 100% after inhalation.
- AF for dose response relationship:
- 1
- Justification:
- NOAEL used as starting point
- AF for differences in duration of exposure:
- 2
- Justification:
- subchronic to chronic
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- already included in route to route extrapolation
- AF for other interspecies differences:
- 2.5
- Justification:
- Default factor for remaining differences
- AF for intraspecies differences:
- 5
- Justification:
- Default factor for workers
- AF for the quality of the whole database:
- 1
- Justification:
- GLP guideline study
- AF for remaining uncertainties:
- 1
- Justification:
- NOAEL is already worst case due to wide spacing of doses (factor of 10). No additional factor for use of a read across substance was applied.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 12.8 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 1 275 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- For the risk assessment 75% absorption is chosen for the oral route and 10% for the dermal route, based on LogPow > 4, MW and water solubility
- AF for dose response relationship:
- 1
- Justification:
- NOAEL used as starting point
- AF for differences in duration of exposure:
- 2
- Justification:
- subchronic to chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- This factor describes the differences in metabolic rate between rats and humans based on body weight and is generally applicable to renally excreted substances.
- AF for other interspecies differences:
- 2.5
- Justification:
- Default factor for remaining differences
- AF for intraspecies differences:
- 5
- Justification:
- Default factor for workers
- AF for the quality of the whole database:
- 1
- Justification:
- GLP guideline study
- AF for remaining uncertainties:
- 1
- Justification:
- NOAEL is already worst case due to wide spacing of doses (factor of 10). No additional factor for use of a read across substance was applied.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
Acute toxicity
A DNEL acute should be established for substances if an acute hazard toxicity (leading to C&L) has been identified and a potential for high peak exposures exists. Since DEHA is not classified for acute toxicity, a DNEL acute is not required.
Local effects
Since no local effects were described, the DNELs are based on the systemic effects only.
LONG -TERM DNEL
The long-term DNEL is based on the most critical NOAEL of 170mg/kg seen in the one-generation study (reduced body weight gain in maternal animals and offspring). The selection follows the precautionary principle, since no effects on body or organ weights were observed in further subchronic and chronic studies up to 630mg/kg (DEHA) and 500mg/kg (DINA). For DEHA, blood and urine parameteres were only assessed in a 28 -day repeated dose, but no changes were observed up to 1000mg/kg.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 2.2 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 50
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 110.9 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- The NOAEL from the oral one-generation study was converted to an inhalation NOAEC according to the following formula. NOAEC = NOAEL / resp. volume (rat) x (absorption (oral) / absorption (inhal.)) = 170mg/kg b.w. / 1.15m³/kg b.w. x 0.75 / 1 = 110.9 mg/m³. Based on toxicokinetic data absorption was considered to be 75% after oral exposure and 100% after inhalation.
- AF for dose response relationship:
- 1
- Justification:
- NOAEL used as starting point
- AF for differences in duration of exposure:
- 2
- Justification:
- subchronic to chronic
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Already included in route to route extrapolation
- AF for other interspecies differences:
- 2.5
- Justification:
- Default factor for remaining differences
- AF for intraspecies differences:
- 10
- Justification:
- Default factor for consumers
- AF for the quality of the whole database:
- 1
- Justification:
- GLP guideline study
- AF for remaining uncertainties:
- 1
- Justification:
- NOAEL is already worst case due to wide spacing of doses (factor of 10). No additional factor for use of a read across substance was applied.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 6.4 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 200
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 1 275 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- For the risk assessment 75% absorption is chosen for the oral route and 10% for the dermal route, based on LogPow > 4, MW and water solubility
- AF for dose response relationship:
- 1
- Justification:
- NOAEL used as starting point
- AF for differences in duration of exposure:
- 2
- Justification:
- subchronic to chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- This factor describes the differences in metabolic rate between rats and humans based on body weight and is generally applicable to renally excreted substances.
- AF for other interspecies differences:
- 2.5
- Justification:
- Default factor for remaining differences
- AF for intraspecies differences:
- 10
- Justification:
- Default factor for consumer
- AF for the quality of the whole database:
- 1
- Justification:
- GLP guideline study
- AF for remaining uncertainties:
- 1
- Justification:
- NOAEL is already worst case due to wide spacing of doses (factor of 10). No additional factor for use of a read across substance was applied.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.85 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 200
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 170 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- not required, no difference in oral absorption between rats and human is expected
- AF for dose response relationship:
- 1
- Justification:
- NOAEL used as starting point
- AF for differences in duration of exposure:
- 2
- Justification:
- subchronic to chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- This factor describes the differences in metabolic rate between rats and humans based on body weight and is generally applicable to renally excreted substances.
- AF for other interspecies differences:
- 2.5
- Justification:
- Default factor for remaining differences
- AF for intraspecies differences:
- 10
- Justification:
- Default factor for consumers
- AF for the quality of the whole database:
- 1
- Justification:
- GLP guideline study
- AF for remaining uncertainties:
- 1
- Justification:
- NOAEL is already worst case due to wide spacing of doses (factor of 10). No additional factor for use of a read across substance was applied.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Acute toxicity
A DNEL acute should be established for substances if an acute hazard toxicity (leading to C&L) has been identified and a potential for high peak exposures exists. Since DEHA is not classified for acute toxicity, a DNEL acute is not needed.
Local effects
Since no local effects were described, the DNELs are based on the systemic effects only
LONG -TERM DNEL
The long-term DNEL is based on the most critical NOAEL of 170mg/kg seen in the one-generation study (reduced body weight gain in maternal animals and offspring). The selection follows the precautionary principle, since no effects on body or organ weights were observed in further subchronic and chronic studies up to 630mg/kg (DEHA) and 500mg/kg (DINA). For DEHA, blood and urine parameteres were only assessed in a 28 -day repeated dose, but no changes were observed up to 1000mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.