Registration Dossier
Registration Dossier
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EC number: 251-136-4 | CAS number: 32647-67-9
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experimental starting date: 01 June 2017; Experimental completion date: 13 September 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 13 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- >= 5 - <= 6.9
- Conclusions:
- The water solubility of the test item has been determined to be 1.30 x 10-2 g/L of solution at 20.0 ± 0.5 °C.
- Executive summary:
The determination was carried out using a flask method designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
The water solubility of the test item has been determined to be 1.30 x 10-2 g/L of solution at 20.0 ± 0.5 °C.
Reference
Preliminary Test:
The preliminary estimate of water solubility was 1.73 x 10-2 g/L at 20.0 ± 0.5°C.
Main Test and Extended Saturation Period Test:
The concentration (g/L) of test item in the sample solutions is shown in the following table:
Sample number |
Time shaken at 30 ºC (hours) |
Time equilibrated at 20 ºC (hours) |
Mean concentration (g/L) |
Solution pH |
1 |
24 |
24 |
1.31 x 10-2 |
6.9 |
2 |
48 |
24 |
1.35 x 10-2 |
6.8 |
3 |
72 |
24 |
1.44 x 10-2 |
6.8 |
4 |
96 |
24 |
1.21 x 10-2 |
5.6 |
5 |
120 |
24 |
1.18 x 10-2 |
5.6 |
6 |
144 |
24 |
1.29 x 10-2 |
5.0 |
Mean concentration : 1.30 x 10-2 g/L
at 20.0 ± 0.5 ºC
Range : 1.18 x 10-2 to 1.44
x 10-2 g/L
Standard Deviation : 9.56 x 10-4
Validation:
The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 5.0 to 50.0 mg/L. The results were satisfactory with a first order correlation coefficient (r) of 0.9996 being obtained.
Description of key information
The determination was carried out using a flask method designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
The water solubility of the test item has been determined to be 1.30 x 10-2 g/L of solution at 20.0 ± 0.5 °C.
Key value for chemical safety assessment
- Water solubility:
- 0.013 g/L
- at the temperature of:
- 20 °C
Additional information
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