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Diss Factsheets
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EC number: 248-890-1 | CAS number: 28188-41-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
Skin sensitization:
The dermal irritation potential of 3-(bromomethyl)benzonitrile was estimated using OECD QSAR toolbox v3.3 with logPow as the primary descriptor.
3-(bromomethyl)benzonitrile was estimated to be corrosive to the skin of New Zealand White rabbits.
Based on the estimated results, 3-(bromomethyl)benzonitrile can be considered to be irritating to skin and can be classified under the category “ Category 1(corrosive) based on GHS criteria ” as per CLP regulation.
Eye irritation:
The ocular irritation potential of 3-(bromomethyl)benzonitrile was estimated using OECD QSAR toolbox v3.3 with logPow as the primary descriptor.
3-(bromomethyl)benzonitrile was estimated to be irritating to the eye of New Zealand White rabbits.
Based on the estimated results, 3-(bromomethyl)benzonitrile can be considered to be irritating to eye and can be classified under the category “ Category 2 (irritant) based on GHS criteria ” as per CLP regulation.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data is predicted using OECD QSAR toolbox version 3.3 and QMRF report has been attached
- Qualifier:
- according to guideline
- Guideline:
- other: estimated data
- Principles of method if other than guideline:
- Prediction was done by using OECD QSAR toolbox v3.3
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of the test material: α-bromo-m-toluonitrile
- IUPAC name: 3-(bromomethyl)benzonitrile
- Molecular formula: C8H6BrN
- Molecular weight: 196.046 g/mol
- Smiles: N#Cc1cc(CBr)ccc1
- Inchi: 1S/C8H6BrN/c9-5-7-2-1-3-8(4-7)6-10/h1-4H,5H2
- Substance type: Organic
- Physical state : Solid crystalline powder (Off white) - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- No data available
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- No data available
- Duration of treatment / exposure:
- No data available
- Observation period:
- No data available
- Number of animals:
- No data available
- Details on study design:
- No data available
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: Not specified
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- positive indication of irritation estimated
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- 3-(bromomethyl)benzonitrile was considered to be skin irritant on New Zealand White Rabbit.
- Executive summary:
The dermal irritation potential of 3-(bromomethyl)benzonitrile was estimated using OECD QSAR toolbox v3.3 with logPow as the primary descriptor.
3-(bromomethyl)benzonitrile was estimated to be irritating to the skin of New Zealand White rabbits.
Based on the estimated results, 3-(bromomethyl)benzonitrile can be considered to be irritating to skin and can be classified under the category “ Category 1B (corrosive) based on GHS criteria ” as per CLP regulation.
Reference
Estimation
method: Takes mode value from the 6 nearest neighbours
Domain logical expression:Result: In Domain
((((("a"
or "b" or "c" or "d" or "e" )
and "f" )
and ("g"
and (
not "h")
)
)
and ("i"
and (
not "j")
)
)
and ("k"
and "l" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Benzyl Halides by Aquatic
toxicity classification by ECOSAR
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as SN2 OR SN2 >> SN2 reaction at
sp3 carbon atom OR SN2 >> SN2 reaction at sp3 carbon atom >> Alkyl
halides OR SN2 >> SN2 reaction at sp3 carbon atom >> alpha-Halobenzyls
(and related cyano, sulfate and sulphonate subs. chem.) by Protein
binding by OECD ONLY
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as SN2 OR SN2 >> Nucleophilic
substitution at sp3 carbon atom OR SN2 >> Nucleophilic substitution at
sp3 carbon atom >> Alkyl halides OR SN2 >> Nucleophilic substitution on
benzilyc carbon atom OR SN2 >> Nucleophilic substitution on benzilyc
carbon atom >> alpha-Activated benzyls by Protein binding by OASIS v1.3
ONLY
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as SN2 OR SN2 >> SN2 at an sp3
Carbon atom OR SN2 >> SN2 at an sp3 Carbon atom >> Aliphatic halides by
DNA binding by OECD ONLY
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as AN2 OR AN2 >> Shiff base
formation for aldehydes OR AN2 >> Shiff base formation for aldehydes >>
Haloalkane Derivatives with Labile Halogen OR SN2 OR SN2 >> Acylation
involving a leaving group OR SN2 >> Acylation involving a leaving group
>> Haloalkane Derivatives with Labile Halogen OR SN2 >> Alkylation,
nucleophilic substitution at sp3-carbon atom OR SN2 >> Alkylation,
nucleophilic substitution at sp3-carbon atom >> Haloalkane Derivatives
with Labile Halogen by DNA binding by OASIS v.1.3 ONLY
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as AN2 AND AN2 >> Shiff base
formation for aldehydes AND AN2 >> Shiff base formation for aldehydes >>
Haloalkane Derivatives with Labile Halogen AND SN2 AND SN2 >> Acylation
involving a leaving group AND SN2 >> Acylation involving a leaving
group >> Haloalkane Derivatives with Labile Halogen AND SN2 >>
Alkylation, nucleophilic substitution at sp3-carbon atom AND SN2 >>
Alkylation, nucleophilic substitution at sp3-carbon atom >> Haloalkane
Derivatives with Labile Halogen by DNA binding by OASIS v.1.3 ONLY
Domain
logical expression index: "g"
Referential
boundary: The
target chemical should be classified as (!Undefined)Group All Lipid
Solubility < 0.01 g/kg AND (!Undefined)Group CNHal Lipid Solubility < 4
g/kg AND (!Undefined)Group CNHal Lipid Solubility < 400 g/kg by Skin
irritation/corrosion Exclusion rules by BfR
Domain
logical expression index: "h"
Referential
boundary: The
target chemical should be classified as Group All log Kow < -3.1 OR
Group CNHal Aqueous Solubility < 0.1 g/L OR Group CNHal log Kow > 3.8 by
Skin irritation/corrosion Exclusion rules by BfR
Domain
logical expression index: "i"
Referential
boundary: The
target chemical should be classified as Acetylenic Carbon [#C] AND
Aliphatic Carbon [CH] AND Aliphatic Carbon [-CH2-] AND Aromatic Carbon
[C] AND Bromine, aliphatic attach [-Br] AND Cyano, aromatic attach
[-C#N] AND Olefinic carbon [=CH- or =C<] by Organic functional groups
(US EPA)
Domain
logical expression index: "j"
Referential
boundary: The
target chemical should be classified as Alcohol, olefinic attach [-OH]
by Organic functional groups (US EPA)
Domain
logical expression index: "k"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= 0.718
Domain
logical expression index: "l"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 2.85
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data is predicted using OECD QSAR toolbox version 3.3 and QMRF report has been attached
- Qualifier:
- according to guideline
- Guideline:
- other: estimated data
- Principles of method if other than guideline:
- Prediction was done by using OECD QSAR toolbox v3.3
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of the test material: α-bromo-m-toluonitrile
- IUPAC name: 3-(bromomethyl)benzonitrile
- Molecular formula: C8H6BrN
- Molecular weight: 196.046 g/mol
- Smiles: N#Cc1cc(CBr)ccc1
- Inchi: 1S/C8H6BrN/c9-5-7-2-1-3-8(4-7)6-10/h1-4H,5H2
- Substance type: Organic
- Physical state : Solid crystalline powder (Off white) - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- No data available
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- Not specified
- Duration of treatment / exposure:
- Not specified
- Observation period (in vivo):
- Not specified
- Duration of post- treatment incubation (in vitro):
- Not specified
- Number of animals or in vitro replicates:
- Not specified
- Details on study design:
- Not specified
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Interpretation of results:
- Category 2A (irritating to eyes) based on GHS criteria
- Conclusions:
- 3-(bromomethyl)benzonitrile was considered to be eye irritant on New Zealand White Rabbit.
- Executive summary:
The ocular irritation potential of 3-(bromomethyl)benzonitrile was estimated using OECD QSAR toolbox v3.3 with logPow as the primary descriptor.
3-(bromomethyl)benzonitrile was estimated to be irritating to the eye of New Zealand White rabbits.
Based on the estimated results, 3-(bromomethyl)benzonitrile can be considered to be irritating to eye and can be classified under the category “ Category 2 (irritant) based on GHS criteria ” as per CLP regulation.
Reference
Estimation
method: Takes mode value from the 6 nearest neighbours
Domain logical expression:Result: In Domain
(((((((((((((((("a"
or "b" or "c" or "d" or "e" )
and "f" )
and "g" )
and ("h"
and (
not "i")
)
)
and ("j"
and (
not "k")
)
)
and ("l"
and (
not "m")
)
)
and "n" )
and "o" )
and "p" )
and "q" )
and "r" )
and ("s"
and (
not "t")
)
)
and ("u"
and (
not "v")
)
)
and ("w"
and (
not "x")
)
)
and ("y"
and (
not "z")
)
)
and ("aa"
and "ab" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Benzyl Halides by Aquatic
toxicity classification by ECOSAR
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as AN2 OR AN2 >> Shiff base
formation for aldehydes OR AN2 >> Shiff base formation for aldehydes >>
Haloalkane Derivatives with Labile Halogen OR SN2 OR SN2 >> Acylation
involving a leaving group OR SN2 >> Acylation involving a leaving group
>> Haloalkane Derivatives with Labile Halogen OR SN2 >> Alkylation,
nucleophilic substitution at sp3-carbon atom OR SN2 >> Alkylation,
nucleophilic substitution at sp3-carbon atom >> Haloalkane Derivatives
with Labile Halogen by DNA binding by OASIS v.1.3 ONLY
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as SN2 OR SN2 >> SN2 at an sp3
Carbon atom OR SN2 >> SN2 at an sp3 Carbon atom >> Aliphatic halides by
DNA binding by OECD ONLY
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as SN2 OR SN2 >> Nucleophilic
substitution at sp3 carbon atom OR SN2 >> Nucleophilic substitution at
sp3 carbon atom >> Alkyl halides OR SN2 >> Nucleophilic substitution on
benzilyc carbon atom OR SN2 >> Nucleophilic substitution on benzilyc
carbon atom >> alpha-Activated benzyls by Protein binding by OASIS v1.3
ONLY
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as SN2 OR SN2 >> SN2 reaction at
sp3 carbon atom OR SN2 >> SN2 reaction at sp3 carbon atom >> Alkyl
halides OR SN2 >> SN2 reaction at sp3 carbon atom >> alpha-Halobenzyls
(and related cyano, sulfate and sulphonate subs. chem.) by Protein
binding by OECD ONLY
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as SN2 AND SN2 >> Nucleophilic
substitution at sp3 carbon atom AND SN2 >> Nucleophilic substitution at
sp3 carbon atom >> Alkyl halides AND SN2 >> Nucleophilic substitution
on benzilyc carbon atom AND SN2 >> Nucleophilic substitution on benzilyc
carbon atom >> alpha-Activated benzyls by Protein binding by OASIS v1.3
ONLY
Domain
logical expression index: "g"
Referential
boundary: The
target chemical should be classified as Bioavailable by Lipinski Rule
Oasis ONLY
Domain
logical expression index: "h"
Referential
boundary: The
target chemical should be classified as Halogens AND Non-Metals by
Groups of elements
Domain
logical expression index: "i"
Referential
boundary: The
target chemical should be classified as Metalloids by Groups of elements
Domain
logical expression index: "j"
Referential
boundary: The
target chemical should be classified as Group 14 - Carbon C AND Group 15
- Nitrogen N AND Group 17 - Halogens Br AND Group 17 - Halogens
F,Cl,Br,I,At by Chemical elements
Domain
logical expression index: "k"
Referential
boundary: The
target chemical should be classified as Group 15 - Phosphorus P by
Chemical elements
Domain
logical expression index: "l"
Referential
boundary: The
target chemical should be classified as Group 14 - Carbon C AND Group 15
- Nitrogen N AND Group 17 - Halogens Br AND Group 17 - Halogens
F,Cl,Br,I,At by Chemical elements
Domain
logical expression index: "m"
Referential
boundary: The
target chemical should be classified as Group 16 - Oxygen O by Chemical
elements
Domain
logical expression index: "n"
Referential
boundary: The
target chemical should be classified as Alkyl halide AND Aryl AND Benzyl
AND Nitrile by Organic Functional groups ONLY
Domain
logical expression index: "o"
Referential
boundary: The
target chemical should be classified as Alkyl halide AND Aryl AND Benzyl
AND Nitrile by Organic Functional groups ONLY
Domain
logical expression index: "p"
Referential
boundary: The
target chemical should be classified as Alkyl halide AND Aryl AND Benzyl
AND Nitrile by Organic Functional groups ONLY
Domain
logical expression index: "q"
Referential
boundary: The
target chemical should be classified as Benzyl AND Nitrile AND
Overlapping groups by Organic Functional groups (nested) ONLY
Domain
logical expression index: "r"
Referential
boundary: The
target chemical should be classified as Benzyl AND Nitrile AND
Overlapping groups by Organic Functional groups (nested) ONLY
Domain
logical expression index: "s"
Referential
boundary: The
target chemical should be classified as (!Undefined)Group All Lipid
Solubility < 0.01 g/kg AND (!Undefined)Group CNHal Lipid Solubility < 4
g/kg AND (!Undefined)Group CNHal Lipid Solubility < 400 g/kg by Skin
irritation/corrosion Exclusion rules by BfR
Domain
logical expression index: "t"
Referential
boundary: The
target chemical should be classified as Group CHal log Kow > 4.5 by Skin
irritation/corrosion Exclusion rules by BfR
Domain
logical expression index: "u"
Referential
boundary: The
target chemical should be classified as SN2 AND SN2 >> Nucleophilic
substitution on benzilyc carbon atom AND SN2 >> Nucleophilic
substitution on benzilyc carbon atom >> alpha-Activated benzyls by
Protein binding alerts for skin sensitization by OASIS v1.3
Domain
logical expression index: "v"
Referential
boundary: The
target chemical should be classified as SN2 >> Nucleophilic substitution
at sp3 carbon atom >> Alkyl halides by Protein binding alerts for skin
sensitization by OASIS v1.3
Domain
logical expression index: "w"
Referential
boundary: The
target chemical should be classified as No alert found by Protein
binding alerts for Chromosomal aberration by OASIS v1.1
Domain
logical expression index: "x"
Referential
boundary: The
target chemical should be classified as SN2 >> Nucleophilic subsitution
at sp3- Carbon atom >> alpha, omega-Dihaloalkanes by Protein binding
alerts for Chromosomal aberration by OASIS v1.1
Domain
logical expression index: "y"
Referential
boundary: The
target chemical should be classified as AN2 AND AN2 >> Shiff base
formation for aldehydes AND AN2 >> Shiff base formation for aldehydes >>
Haloalkane Derivatives with Labile Halogen AND SN2 AND SN2 >> Acylation
involving a leaving group AND SN2 >> Acylation involving a leaving
group >> Haloalkane Derivatives with Labile Halogen AND SN2 >>
Alkylation, nucleophilic substitution at sp3-carbon atom AND SN2 >>
Alkylation, nucleophilic substitution at sp3-carbon atom >> Haloalkane
Derivatives with Labile Halogen by DNA alerts for AMES, MN and CA by
OASIS v.1.3
Domain
logical expression index: "z"
Referential
boundary: The
target chemical should be classified as SN2 >> Nucleophilic substitution
after carbenium ion formation by DNA alerts for AMES, MN and CA by OASIS
v.1.3
Domain
logical expression index: "aa"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= 2.01
Domain
logical expression index: "ab"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 3.14
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation:
In different studies, 3-(bromomethyl)benzonitrile has been investigated for potential for dermal irritation to a greater or lesser extent. The studies are based on in vivo experiments in rabbits along with human data for target chemical
3-(bromomethyl)benzonitrile and its structurally similar read across substances Benzonitrile (CAS: 100-47-0) and Phenylacetonitrile (CAS: 140-29-4). The predicted data using the OECD QSAR toolbox has also been compared with the experimental data.
The dermal irritation potential of 3-(bromomethyl)benzonitrile was estimated using OECD QSAR toolbox v3.3 with logPow as the primary descriptor.
3-(bromomethyl)benzonitrile was estimated to be irritating to the skin of New Zealand White rabbits.
Based on the estimated results, 3-(bromomethyl)benzonitrile can be considered to be irritating to skin and can be classified under the category “ Category 2 (irritant) based on GHS criteria ” as per CLP regulation.
The above predicted data was supported by experimental data summarized in GESTIS - Substance Database (Information system on hazardous substances of the Benzonitrile ) 2017 for the structurally similar read across substance Benzonitrile (CAS: 100-47-0)
Benzonitrile was used as a test material to evaluate skin irritation potential on rabbits.
The test material was applied on the intact or scarified rabbit skin in undiluted concentration under occlusion for 24 hrs. Slight irritation reactions were observed. Hence, Benzonitrile was considered to be skin irritant.
The above experimental result was further supported by experimental data summarized by Hazardous Substances Data Bank (HSDB) for phenylacetonitrile U.S National Library of Medicine 2017 and IUCLID dataset for phenylacetonitrile European Chemicals Bureau 2000 for the structurally similar read across substance Phenylacetonitrile (CAS: 140-29-4).
Phenylacetonitrile was used as a test material to evaluate its skin irritation potential on rabbits.
Phenylacetonitrile was applied onIntact or abraded skin ofrabbits under occlusion for 24 hrs .Positive skin reactions were observed .Hence,Phenylacetonitrile was considered to be slightly irritating.
Even though the predicted data for target 3-(bromomethyl)benzonitrile was stated as corrosive , based on the available data of closely related
structurally similar read across substance 3-(bromomethyl)benzonitrile may considered as irritating to skin
Based on the available data for the target 3-(bromomethyl)benzonitrile and read across substances and applying the weight of evidence approach,3-(bromomethyl)benzonitrilecan be considered to be irritating to skin.Comparing the above annotations with the criteria of CLP regulation, it can be classified under the category “Category 2 (irritant) based on GHS criteria”.
Eye irritation:
In different studies, 3-(bromomethyl)benzonitrile has been investigated for potential for ocular irritation to a greater or lesser extent. The studies are based on in vivo experiments in rabbits along with human data for target chemical
3-(bromomethyl)benzonitrile and its structurally similar read across substances Benzonitrile (CAS: 100-47-0) and Phenylacetonitrile (CAS: 140-29-4). The predicted data using the OECD QSAR toolbox has also been compared with the experimental data.
The ocular irritation potential of 3-(bromomethyl)benzonitrile was estimated using OECD QSAR toolbox v3.3 with logPow as the primary descriptor.
3-(bromomethyl)benzonitrile was estimated to be irritating to the eye of New Zealand White rabbits.
Based on the estimated results, 3-(bromomethyl)benzonitrile can be considered to be irritating to eye and can be classified under the category “ Category 2 (irritant) based on GHS criteria ” as per CLP regulation.
The above predicted data was supported by experimental data summarized in GESTIS - Substance Database (Information system on hazardous substances of the Benzonitrile ) 2017 for structurally similar read across substance Benzonitrile (CAS: 100-47-0).
Benzonitrile was used as a test material to evaluate its ocular irritation potential on rabbits.
Benzonitrile when administrated on rabbit eye producedreddening of the conjunctiva, no irritation to the cornea and iris, minor vascular injection. These reactions were reversible after 10 days. Based on the ocular reactions Benzonitrile was considered to be slight eye irritant.
The above experimental data was further supported by experimental data summarized in IUCLID dataset for phenylacetonitrile European Chemicals Bureau 2000 for the structurally similar read across substance Phenylacetonitrile (CAS: 140-29-4).
Phenylacetonitrile was used as a test material to evaluate its ocular irritation potential .
Phenylacetonitrile was subjected to rabbit eye which resulted intotransient hyperemia and lachrymation. On the Basis of above ocular reactions phenylacetonitrile was considered to be eye irritating.
Based on the available data for the target 3-(bromomethyl)benzonitrile and read across substances and applying the weight of evidence approach,3-(bromomethyl)benzonitrilecan be considered to be irritating to eye.Comparing the above annotations with the criteria of CLP regulation, it can be classified under the category “Category 2 (irritant) based on GHS criteria”.
Justification for classification or non-classification
Even though the predicted data for target 3-(bromomethyl)benzonitrile was stated as corrosive , based on the available data of closely related
structurally similar read across substance 3-(bromomethyl)benzonitrile may considered as irritating to skin .
Based on the available data for the target 3-(bromomethyl)benzonitrile and read across substances and applying the weight of evidence approach,3-(bromomethyl)benzonitrilecan be considered to be irritating to skin and eye.Comparing the above annotations with the criteria of CLP regulation, it can be classified under the category “Category 2 (irritant) based on GHS criteria”.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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