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EC number: 244-334-7 | CAS number: 21324-40-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dissociation constant
Administrative data
- Endpoint:
- dissociation constant
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is hydrolytically unstable (half-life less than 12 hours)
Cross-reference
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Adequately documented investigation of hydrolysis rate in contact with water and atmospheric moisture, using non-standard methodology which is however suitable for the particular properties of the test substance.
- Principles of method if other than guideline:
- [1] Observation of speed of dissolution and hydrolysis in water by measurement of HF formation by pH determination and LiF formation by pF determination.
[2] Observation of reaction with atmospheric moisture by accurate monitoring of sample weight change. - GLP compliance:
- not specified
- Remarks:
- This study was a bespoke test performed by the manufacturer of the substance. This study was not carried out specifically for REACH, however it provides key information to show the substance is hydrolytically unstable and relevant for risk assessment.
- Analytical monitoring:
- yes
- Details on test conditions:
- Hydrolysis on contact with water.
Experiment 1:
5g samples of test material added to 500 ml volumes of water with stirring - test run with water at 20, 30, 40, 50 and 60C. pH and pF recorded at start (T0) and when reaction appeared complete, as judged by pH/pF change (15-21 seconds after sample addition).
Experiment2:
different amounts of test substance (5-50g) added to 500 ml volumes of water with stirring, at 20C. pH and pF recorded at start (T0) and when reaction appeared complete, as judged by pH/pF change (21-49 seconds after sample addition).
Experiment 3:
30g samples of test material added to 500 ml volumes of water with stirring - test run with water at 20, 30, 40, 50 and 60C. pH and pF recorded at start (T0) and at intervals until the reaction appeared complete, as judged by pH/pF change (11-42 seconds after sample addition).
Reaction with atmospheric moisture.
Experiment 1:
approximately 1g samples of test material (accurately weighed to 0.1 mg) exposed to high humidity atmospheres (84.4-93.6% RH) for up to 150 minutes, with accurate recording of sample mass at frequent intervals. Separate determinations for two test samples showing some difference in particle size (designated big and small).
Experiment 2:
3 further determinations of sample mass change in moist air of differing RH (54.7-85.8%), over time periods up to 160 minutes and using the test material designated small particle size. - Number of replicates:
- Hydrolysis in contact with water: 3 experiments, 5 different test temperatures.
Reaction with atmospheric moisture: 2 experiments, different RH levels and sample particulate sizes. - Statistical methods:
- Not applicable
- Transformation products:
- yes
- No.:
- #1
- No.:
- #2
- No.:
- #3
- Details on hydrolysis and appearance of transformation product(s):
- It was known that the test substance reacts rapidly with water, releasing HF/hydrofluoric acid, LiF and phosphoric acid. The hydrolysis reaction was followed by measurement of pH and PF.
Reaction with atmospheric moisture was shown to follow a biphasic pattern: an initial increase considered to reflect water absorption was followed by a decrease associated with release of POF3 and HF. - DT50:
- < 3 s
- Type:
- not specified
- Remarks on result:
- other: hydrolysis rate constant not determined
- Conclusions:
- Rapid reaction with water releases HF and LiF, leading to production of dissolved F- ions; subsequently, release of Li+ and PO4(3-) ions will follow.
Reaction with water: Experiment 1
Sample number |
Temperature[C] |
Sample weight |
pH Start |
pH End |
pF Start |
pF End |
End time (secs) |
1 |
20 |
5.06 |
6.35 |
4.32 |
7.05 |
4.46 |
20 |
2 |
30 |
5.03 |
6.52 |
4.57 |
8.51 |
4.91 |
15 |
3 |
40 |
5.05 |
6.02 |
4.66 |
7.03 |
4.84 |
20 |
4 |
50 |
5.04 |
5.87 |
4.65 |
6.63 |
4.91 |
20 |
5 |
60 |
5.02 |
6.00 |
4.60 |
7.20 |
5.05 |
21 |
Reaction with water: Experiment 2
Sample number |
Temperature[C] |
Sample weight |
pH Start |
pH End |
pF Start |
pF End |
End time (secs) |
1 |
20 |
5 |
6.00 |
4.60 |
7.20 |
5.05 |
21 |
2 |
20 |
20 |
7.45 |
3.17 |
7.18 |
3.18 |
31 |
3 |
20 |
30 |
6.23 |
3.52 |
7.23 |
3.71 |
42 |
4 |
20 |
40 |
6.43 |
3.06 |
7.32 |
3.31 |
49 |
5 |
20 |
50 |
6.25 |
3.08 |
7.12 |
3.48 |
32 |
Reaction with water: Experiment 3 (summarised)
Sample number |
Temperature[C] |
Sample weight |
pH Start |
pH End |
pF Start |
pF End |
End time (secs) |
1 |
20 |
30 |
6.23 |
3.52 |
7.23 |
3.71 |
42 |
2 |
30 |
30 |
6.53 |
3.32 |
7.68 |
3.74 |
22 |
3 |
40 |
30 |
5.70 |
3.53 |
6.76 |
3.96 |
16 |
4 |
50 |
30 |
5.39 |
2.70 |
6.18 |
3.37 |
29 |
5 |
60 |
30 |
5.70 |
1.75 |
6.06 |
3.05 |
11 |
Reaction with water: Experiment 3 (full results)
Temperature 20 C sample 30g |
Temperature 30 C sample 30g |
Temperature 40 C sample 30g |
||||||
Time (secs) |
pH |
pF |
time |
pH |
pF |
time |
pH |
pF |
0 |
6.23 |
7.23 |
0 |
6.53 |
7.68 |
0 |
5.70 |
6.76 |
3 |
3.55 |
3.75 |
3 |
3.35 |
3.77 |
3 |
3.56 |
3.99 |
5 |
3.55 |
3.74 |
5 |
3.34 |
3.76 |
5 |
3.55 |
3.98 |
10 |
3.54 |
3.73 |
10 |
3.33 |
3.75 |
10 |
3.54 |
3.97 |
20 |
3.53 |
3.73 |
22 |
3.32 |
3.74 |
16 |
3.53 |
3.96 |
30 |
3.53 |
3.72 |
- |
- |
- |
- |
- |
- |
42 |
3.52 |
3.71 |
- |
- |
- |
- |
- |
- |
Temperature 50 C sample 30g |
Temperature 60 C sample 30g |
|
|
|
||||
Time (secs) |
pH |
pF |
time |
pH |
pF |
|
|
|
0 |
5.39 |
6.18 |
0 |
5.70 |
6.06 |
|
|
|
3 |
2.75 |
3.40 |
3 |
1.77 |
3.07 |
|
|
|
5 |
2.74 |
3.39 |
5 |
1.76 |
3.06 |
|
|
|
10 |
2.73 |
3.38 |
11 |
1.75 |
3.05 |
|
|
|
Moist air reaction, Experiment 1: LPF big particle, 19.6 C, humidity 93.6%
Time [min] |
Mass [g] |
Time [min] |
Mass [g] |
Time [min] |
Mass [g] |
0 |
1.0438 |
60 |
1.0502 |
110 |
1.0761 |
10 |
1.0547 |
70 |
1.0540 |
120 |
1.0802 |
20 |
1.0596 |
80 |
1.0583 |
130 |
1.0864 |
30 |
1.0545 |
90 |
1.0641 |
140 |
1.0902 |
40 |
1.0520 |
100 |
1.0699 |
150 |
1.0974 |
50 |
1.0491 |
- |
- |
- |
- |
Mass increase: (1.0596-1.0438) /1.0438=1.5% time: 20min. Mass decrease: (1.0596-1.0491) /1.0596=0.99% time: 30min.
Moist air reaction, Experiment 1: LPF small particle, 20.7 C, humidity 84.4%
Time [min] |
Mass [g] |
Time [min] |
Mass [g] |
Time [min] |
Mass [g] |
0 |
1.0049 |
30 |
1.0071 |
60 |
0.9970 |
5 |
1.0095 |
35 |
1.0039 |
65 |
0.9977 |
10 |
1.0133 |
40 |
1.0008 |
70 |
0.9987 |
15 |
1.0137 |
45 |
0.9988 |
75 |
0.9998 |
20 |
1.0125 |
50 |
0.9977 |
80 |
1.0010 |
25 |
1.0097 |
55 |
0.9973 |
85 |
1.0025 |
Mass increase: (1.0137-1.0049) /1.0049=0.87% time: 15min. Mass decrease: (1.0137-0.9970) /1.0137=1.65% time: 45min.
Moist air reaction, Experiment 2: LPF small particle, 20.7 C, humidity 85.8%
Time [min] |
Mass [g] |
Time [min] |
Mass [g] |
Time [min] |
Mass [g] |
0 |
1.0462 |
25 |
1.0456 |
50 |
1.0468 |
5 |
1.0491 |
30 |
1.0444 |
55 |
1.0482 |
10 |
1.0520 |
35 |
1.0438 |
60 |
1.0497 |
15 |
1.0496 |
40 |
1.0441 |
65 |
1.0511 |
20 |
1.0478 |
45 |
1.0451 |
70 |
1.0524 |
Mass increase: (1.0520-1.0462) /1.0462=0.55% time: 10min. mass decrease: (1.0520-1.0438) /1.0520=0.78% time: 25min.
Moist air reaction, Experiment 2: LPF small particle, 20.4 C, humidity 65.1%
Time [min] |
Mass [g] |
Time [min] |
Mass [g] |
Time [min] |
Mass [g] |
0 |
1.0201 |
35 |
1.0031 |
70 |
0.9991 |
5 |
1.0235 |
40 |
1.0008 |
75 |
1.0002 |
10 |
1.0238 |
45 |
0.9992 |
80 |
1.0008 |
15 |
1.0201 |
50 |
0.9992 |
85 |
1.0010 |
20 |
1.0155 |
55 |
0.9990 |
90 |
1.0028 |
25 |
1.0113 |
60 |
0.9988 |
95 |
1.0037 |
30 |
1.0070 |
65 |
0.9987 |
100 |
1.0047 |
Mass increase: (1.0238-1.0201) /1.0201=0.36% time: 10min. Mass decrease: (1.0238-0.9987) /1.0238=0.25% time: 55min.
Moist air reaction, Experiment 2: LPF small particle, 21.5 C, humidity 54.7%
Time [min] |
Mass [g] |
Time [min] |
Mass [g] |
Time [min] |
Mass [g] |
0 |
1.0567 |
55 |
1.0194 |
110 |
1.0073 |
5 |
1.0585 |
60 |
1.0177 |
115 |
1.0070 |
10 |
1.0596 |
65 |
1.0159 |
120 |
1.0064 |
15 |
1.0599 |
70 |
1.0143 |
125 |
1.0054 |
20 |
1.0571 |
75 |
1.0119 |
130 |
1.0060 |
25 |
1.0533 |
80 |
1.0110 |
135 |
1.0058 |
30 |
1.0479 |
85 |
1.0114 |
140 |
1.0057 |
35 |
1.0440 |
90 |
1.0101 |
145 |
1.0056 |
40 |
1.0381 |
95 |
1.0097 |
150 |
1.0065 |
45 |
1.0265 |
100 |
1.0092 |
155 |
1.0080 |
50 |
1.0226 |
105 |
1.0074 |
160 |
1.0088 |
Mass decrease: (1.0599-1.0567) /1.0567=0.30% time: 15min. Mass decrease: (1.0599-1.0056) /1.0599=5.12% time: 130min.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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